55080
8-Quinolinol
purum, ≥95.0% (NT)
Synonym(s):
8-Hydroxyquinoline, 8-Oxychinolin, Oxine
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About This Item
Empirical Formula (Hill Notation):
C9H7NO
CAS Number:
Molecular Weight:
145.16
EC Number:
205-711-1
UNSPSC Code:
12352100
Beilstein/REAXYS Number:
114512
MDL number:
grade
purum
assay
≥95.0% (NT)
mp
70-74 °C, 72.5-74.0 °C
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
CCCCCCCC\C=C/CCCCCCCC(O)=O, Oc1cccc2cccnc12
InChI
1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
InChI key
MCJGNVYPOGVAJF-UHFFFAOYSA-N
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General description
Chemical structure: quinolone
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María Isabel Fernández-Bachiller et al.
Journal of medicinal chemistry, 53(13), 4927-4937 (2010-06-16)
Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit cholinesterases and decrease beta-amyloid (Abeta) levels by complexation of redox-active metals, respectively. In this work, novel tacrine-8-hydroxyquinoline hybrids have been designed, synthesized, and evaluated as potential multifunctional drugs for
Mahmud Tareq Hassan Khan et al.
Journal of medicinal chemistry, 52(1), 48-61 (2008-12-17)
In the present work, 22 compounds of the U.S. NCI compound library (size 273K) were identified as putative thermolysin binders by structure based virtual screening with the ICM software (ICM-VLS). In vitro competitive binding assays confirmed that 12 were thermolysin
Tomoko Fukuuchi et al.
Bioorganic & medicinal chemistry letters, 16(23), 5982-5987 (2006-09-22)
Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated that compounds with copper-selective chelating ability
Gemma O'Donnell et al.
Journal of natural products, 72(3), 360-365 (2008-12-20)
From Allium stipitatum, three pyridine-N-oxide alkaloids (1-3) possessing disulfide functional groups were isolated. The structures of these natural products were elucidated by spectroscopic means as 2-(methyldithio)pyridine-N-oxide (1), 2-[(methylthiomethyl)dithio]pyridine-N-oxide (2), and 2,2'-dithio-bis-pyridine-N-oxide (3). The proposed structure of 1 was confirmed by
Jane Greeff et al.
Bioorganic & medicinal chemistry, 20(2), 809-818 (2011-12-27)
Neurodegenerative disorders are frequently associated with increased oxidative damage to the brain as a result of free radicals produced by cellular respiration. The onset and progression of neurodegeneration may therefore be curbed by exogenous hydrogen-donating antioxidant moieties such as the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A022-25MG | 04061832088525 |
| A022-250MG | 04061832281261 |
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