55291
Hydroxyurea
≥98.0% (N)
Synonym(s):
Hydroxycarbamide
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About This Item
Linear Formula:
NH2CONHOH
CAS Number:
Molecular Weight:
76.05
EC Number:
204-821-7
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
1741548
MDL number:
assay
≥98.0% (N)
mp
135-140 °C
SMILES string
NC(=O)NO
InChI
1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI key
VSNHCAURESNICA-UHFFFAOYSA-N
Gene Information
human ... CA1(759), CA2(760), CYP1A2(1544), RRM1(6240)
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Biochem/physiol Actions
Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 36173-100MG | 04061831824445 |
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