56802
5H-Dibenz[b,f]azepine
purum, ≥97.0% (NT)
Synonym(s):
Iminostilbene
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About This Item
Empirical Formula (Hill Notation):
C14H11N
CAS Number:
Molecular Weight:
193.24
EC Number:
205-970-0
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
1343358
MDL number:
InChI key
LCGTWRLJTMHIQZ-UHFFFAOYSA-N
InChI
1S/C14H11N/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)15-13/h1-10,15H
SMILES string
N1c2ccccc2C=Cc3ccccc13
grade
purum
assay
≥97.0% (NT)
form
powder
color
yellow to orange
solubility
dioxane: 50 mg/mL, clear
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2
Storage Class
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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B Moosmann et al.
Biological chemistry, 382(11), 1601-1612 (2002-01-05)
Oxidative stress is a widespread phenomenon in the pathology of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Neuronal cell death due to oxidative stress may causally contribute to the pathogeneses of these diseases. Therefore, neuroprotective
S M Furst et al.
Drug metabolism and disposition: the biological fate of chemicals, 23(5), 590-594 (1995-05-01)
Carbamazepine therapy is associated with several types of idiosyncratic drug reactions, including hematological disorders. In previous studies, we found that carbamazepine was metabolized by the myeloperoxidase/H2O2 system of activated neutrophils, and covalent binding of the drug to neutrophils was observed.
A Varenne et al.
Journal of immunological methods, 186(2), 195-204 (1995-10-26)
As part of our ongoing work to extend the range of applications of the non-isotopic carbonyl metalloimmunoassay (CMIA), previously developed in our laboratory, we describe here the first CMIA study of carbamazepine. The CMIA method uses a metal carbonyl complex
Ying Wu et al.
The Journal of allergy and clinical immunology, 118(1), 233-241 (2006-07-04)
T-cell-mediated hypersensitivity is a rare but serious manifestation of drug therapy. To explore the mechanisms of drug presentation to T cells and the possibility that generation of metabolite-specific T cells may provoke cross-sensitization between drugs. A lymphocyte transformation test was
S M Furst et al.
Biochemical pharmacology, 45(6), 1267-1275 (1993-03-24)
Carbamazepine is an anticonvulsant which is associated with a significant incidence of hypersensitivity reactions including agranulocytosis. We have postulated that many drug hypersensitivity reactions, especially agranulocytosis and lupus, are due to reactive metabolites generated by the myeloperoxidase (MPO) (EC 1.11.1.7)
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