57859
Sodium iodoacetate
≥99.0% (NT)
Synonym(s):
Iodoacetic acid sodium salt
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About This Item
Linear Formula:
ICH2COONa
CAS Number:
Molecular Weight:
207.93
Beilstein:
4009322
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
Assay
≥99.0% (NT)
mp
208 °C (dec.) (lit.)
storage temp.
−20°C
SMILES string
[Na+].[O-]C(=O)CI
InChI
1S/C2H3IO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1
InChI key
AGDSCTQQXMDDCV-UHFFFAOYSA-M
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Application
Reagent for the modification of cysteine residues in proteins.
Reagent for the modification of cysteine residues in proteins. Used in protein sequencing (including by Sanger in sequencing bovine insulin) to prevent oxidation of -SH sidechains.
Reagent for the modification of cysteine residues in proteins. Used to induce animal osteoarthritis model system, which mimics both symptoms and histopathology of the human disease.
Other Notes
Sulfhydryl reagent
Disclaimer
may discolor to yellowish on storage
Regulatory Information
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F.R. Gurd
Methods in Enzymology, 11, 532-532 (1973)
J L Leonard et al.
Biochimica et biophysica acta, 787(2), 122-130 (1984-06-14)
Pretreatment of renal iodothyronine 5'-deiodinase with sulfhydryl reagents, iodoacetate, iodoacetamide and N-alkylmaleimides, results in irreversible loss of catalytic activity. Iodoacetate and iodoacetamide were the most potent inhibitors, being 100- to 1000-times more potent than N-alkylmaleimides. Iodoacetate and iodoacetamide inactivation followed
K Nakyinsige et al.
Meat science, 98(4), 701-708 (2014-08-05)
This study assessed the effect of gas stunning which has not been conducted until now in comparison with slaughter without stunning on the welfare and meat quality of rabbits. Eighty male New Zealand White rabbits were divided into two groups
Gabor Tuboly et al.
Brain research bulletin, 112, 52-60 (2015-02-14)
Kynurenic acid (KYNA) is a neuroactive metabolite that interacts with NMDA, AMPA/kainate and alpha 7 nicotinic receptors. The goal of this study was to clarify the roles of these receptors in the action of KYNA at a spinal level by
Hyunji Lee et al.
Bioscience, biotechnology, and biochemistry, 78(10), 1703-1709 (2014-10-03)
Deer bone extract has the potential to relieve the discomfort or the articular cartilaginous damage associated with osteoarthritic (OA) and may be useful as a natural supplement for OA treatment without serious side effects. We analyzed the expression of pro-inflammatory
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