58775
Isocitric Dehydrogenase (NADP) from porcine heart
3-8 U/mg protein (~12 mg/ml)
Synonym(s):
threo-Ds-Isocitrate: NADP+ oxidoreductase, ICDH, IDH
form
solution (clear)
specific activity
3-8 U/mg protein (~12 mg/ml)
mol wt
Mr ~61000
color
amber
storage temp.
2-8°C
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Physical form
50% glycerol; EDTA buffer salts, pH ~6.0
Other Notes
1 U corresponds to the amount of enzyme which catalyzes the conversion of 1 μmol isocitrate to α-ketoglutarate at pH 7.4 and 37°C
Sales restrictions may apply
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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O Zalatimo et al.
Advances in experimental medicine and biology, 779, 267-289 (2013-01-05)
Primary brain tumors constitute a substantial public health problem with 66,290 cases diagnosed in the US in 2012, and 13,700 deaths recorded. With discovery of genetic factors associated with specific brain tumor subtypes, the goal of therapy is changing from
Lynn J Poole Perry et al.
American journal of ophthalmology, 155(3), 593-608 (2012-12-12)
To evaluate the cellular nature of and diagnostic terminology used in connection with acquired retinal "vasoproliferative tumors." Retrospective clinicopathologic study. Clinical records and microscopic slides of 4 enucleated globes were reviewed. Special stains and immunohistochemical probes for CD31, CD34, p53
Rikke H Dahlrot et al.
International journal of clinical and experimental pathology, 6(1), 31-40 (2012-12-14)
High-grade gliomas have a dismal prognosis, and prognostic factors are needed to optimize treatment algorithms. In this study we identified clinical prognostic factors as well as the prognostic value of isocitrate dehydrogenase 1 (IDH1) status in a population-based group of
Juan C Begara-Morales et al.
Journal of experimental botany, 64(4), 1121-1134 (2013-01-31)
Protein tyrosine nitration is a post-translational modification mediated by reactive nitrogen species (RNS) that is associated with nitro-oxidative damage. No information about this process is available in relation to higher plants during development and senescence. Using pea plants at different
Varuna Sipayya et al.
Journal of cancer research and therapeutics, 8(4), 598-601 (2013-01-31)
Mutations in the gene encoding isocitrate dehydrogenase (IDH1) have been reported in gliomas. This study analyses a series of 184 glioma cases in a tissue microarray (TMA)-based approach to assess the frequency of R132H point mutations in formalin-fixed, paraffin-embedded tissue
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