59648
(−)-Isoproterenol hydrochloride
≥98.0% (TLC)
Synonym(s):
(−)-Isoprenaline hydrochloride, (−)-N-Isopropyl-L-noradrenaline hydrochloride, (R)-3,4-Dihydroxy-α-(isopropylaminomethyl)benzyl alcohol hydrochloride
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About This Item
Linear Formula:
3,4-(HO)2C6H3CH(OH)CH2NHCH(CH3)2·HCl
CAS Number:
Molecular Weight:
247.72
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
6077193
MDL number:
assay
≥98.0% (TLC)
mp
175 °C (dec.) (lit.)
storage temp.
−20°C
SMILES string
Cl[H].CC(C)NC[C@H](O)c1ccc(O)c(O)c1
InChI
1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/t11-;/m0./s1
InChI key
IROWCYIEJAOFOW-MERQFXBCSA-N
Biochem/physiol Actions
β-adrenoceptor agonist; increases cytosolic cAMP.
Other Notes
A β-adrenergic agonist. Regulation of protein phosphorylation by inotropic agents in isolated rat myocardial cells
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Regulation of protein phosphorylation by inotropic agents in isolated rat myocardial cells.
J J Onorato et al.
The Journal of biological chemistry, 256(20), 10697-10703 (1981-10-25)
F Aura Kullmann et al.
The Journal of pharmacology and experimental therapeutics, 330(3), 704-717 (2009-06-12)
Voiding dysfunctions, including increased voiding frequency, urgency, or incontinence, are prevalent in the postmenopausal population. Beta(3)-adrenergic receptor (beta(3)AR) agonists, which relax bladder smooth muscle, are being developed to treat these conditions. We utilized the rat ovariectomy (OVX) model to investigate
Andreas Bock et al.
Cell, 182(6), 1519-1530 (2020-08-28)
Cells relay a plethora of extracellular signals to specific cellular responses by using only a few second messengers, such as cAMP. To explain signaling specificity, cAMP-degrading phosphodiesterases (PDEs) have been suggested to confine cAMP to distinct cellular compartments. However, measured