60890
Kojic acid
purum, ≥98.0% (HPLC)
Synonym(s):
2-Hydroxymethyl-5-hydroxy-γ-pyrone, 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone
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About This Item
Empirical Formula (Hill Notation):
C6H6O4
CAS Number:
Molecular Weight:
142.11
EC Number:
207-922-4
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
120895
MDL number:
InChI key
BEJNERDRQOWKJM-UHFFFAOYSA-N
InChI
1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
SMILES string
OCC1=CC(=O)C(O)=CO1
grade
purum
assay
≥98.0% (HPLC)
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Biochem/physiol Actions
Tyrosinase inhibitor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Ya-Li Wang et al.
Journal of analytical methods in chemistry, 2018, 2141389-2141389 (2018-06-05)
Tyrosinase (TYR) is a rate-limiting enzyme in the synthesis of melanin, while direct TYR inhibitors are a class of important clinical antimelanoma drugs. This study established a spectrum-effect relationship analysis method and high-performance liquid chromatography-mass spectrometry (LC-MS) analysis method to
Zong-Ping Zheng et al.
Fitoterapia, 83(6), 1008-1013 (2012-06-16)
The phytochemical profiles of Morus australis roots, stems and twigs were firstly compared by HPLC analysis. It was found that Morus australis stem extract mainly contained one known tyrosinase inhibitor, oxyresveratrol, while its root and twig extract might contain some
Jun-Cheol Cho et al.
Bioorganic & medicinal chemistry letters, 22(12), 4159-4162 (2012-05-15)
We synthesized benzoate ester derivatives of kojic acid with and without adamantane moiety. Benzoate derivatives 2a-e that did not contain an adamantane moiety showed potent tyrosinase inhibitory activities. However, depigmenting activity was not noted in a cell-based assay. Contrasting results
G A Burdock et al.
Regulatory toxicology and pharmacology : RTP, 33(1), 80-101 (2001-03-22)
Kojic acid is a fungal metabolite commonly produced by many species of Aspergillus, Acetobacter, and Penicillium. The Aspergillus flavus group has traditionally been used in the production of a number of foods, including miso (soybean paste), shoyu (soy sauce), and
Myeong-Jin Goh et al.
Phytotherapy research : PTR, 26(8), 1107-1112 (2011-12-14)
In this study we investigated the inhibitory effects and possible mechanisms of action of 8'-hydroxydaidzein and 3'-hydroxydaidzein, two ortho-dihydroxyisoflavone derivatives from Korean fermented soybean paste, on melanogenesis in B16 murine melanoma cells. The two hydroxydaidzeins reduced melanin synthesis comparably to
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