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Merck
CN

61750

Lawesson reagent

purum, ≥98.0% (S)

Synonym(s):

2,4-Bis(4-methoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane, 2,4-Bis-(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide, 4-Methoxyphenylthiophosphoric cyclic di(thioanhydride), LR

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About This Item

Empirical Formula (Hill Notation):
C14H14O2P2S4
CAS Number:
Molecular Weight:
404.47
EC Number:
242-855-4
UNSPSC Code:
12352000
PubChem Substance ID:
Beilstein/REAXYS Number:
1024888
MDL number:
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InChI key

CFHGBZLNZZVTAY-UHFFFAOYSA-N

InChI

1S/C14H14O2P2S4/c1-15-11-3-7-13(8-4-11)17(19)21-18(20,22-17)14-9-5-12(16-2)6-10-14/h3-10H,1-2H3

SMILES string

COc1ccc(cc1)P2(=S)SP(=S)(S2)c3ccc(OC)cc3

grade

purum

assay

≥98.0% (S)

mp

228-230 °C

Other Notes

The most efficient thiation reagent known till now, used for the thiation of carboxamides, ketones, lactones and imides, lactames, 3-oxocarboxylic derivatives (amides, esters and nitriles) and thio-S-esters; Selective thionation of oligopeptides; Reviews about LR

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I. Thomsen et al.
Organic Syntheses, 62, 158-158 (1984)
M.P. Cava et al.
Tetrahedron, 41, 5061-5061 (1985)
O.E. Jensen et al.
Tetrahedron, 41, 5595-5595 (1985)
R.A. Cherkasov et al.
Tetrahedron, 41, 2567-2567 (1985)
K. Clausen et al.
Journal of the Chemical Society. Perkin Transactions 1, 785-785 (1984)

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