61855
L-Leucinamide hydrochloride
purum, ≥99.0% (AT)
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About This Item
Linear Formula:
(CH3)2CHCH2CH(NH2)CONH2·HCl
CAS Number:
Molecular Weight:
166.65
EC Number:
233-952-2
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
4237021
MDL number:
InChI key
VSPSRRBIXFUMOU-JEDNCBNOSA-N
InChI
1S/C6H14N2O.ClH/c1-4(2)3-5(7)6(8)9;/h4-5H,3,7H2,1-2H3,(H2,8,9);1H/t5-;/m0./s1
SMILES string
Cl.CC(C)C[C@H](N)C(N)=O
grade
purum
assay
≥99.0% (AT)
optical activity
[α]20/D +10±1°, c = 2% in H2O
optical purity
enantiomeric ratio: ≥99:1 (GC)
mp
245-248 °C, 254-256 °C (lit.)
application(s)
peptide synthesis
Other Notes
Chiral derivatizing agent for acids (as mixed anhydride) to determine the enantiomer ratio
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Measurement of carprofen enantiomer concentrations in plasma and urine using L-leucinamide as the chiral coupling component.
H Spahn et al.
Journal of chromatography, 433, 331-338 (1988-12-09)
[Marked dissociation of leucine aminopeptidase activities by the use of 2 different substrates--application of the methods to lymphatic diseases].
Y Hirasawa et al.
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 45(5), 907-912 (1982-09-01)
Formation of diastereomeric derivatives of 2-arylpropionic acids using L-leucinamide.
H Spahn
Journal of chromatography, 423, 334-339 (1987-12-25)
B Grinde et al.
Acta biologica et medica Germanica, 40(10-11), 1603-1612 (1981-01-01)
An amino acid mixture, specially designed to improve the protein balance in isolated hepatocytes, inhibited lysosomal (propylamine-sensitive) degradation of endogenous proteins by 80-90%. The amino acids had no effect on the degradation of the endocytosed protein asialofetuin, the conclusion being
Formation of diastereomeric derivatives of 2-arylpropionic acids using L-leucinamide: lack of generality.
R Mehvar et al.
Journal of chromatography, 431(1), 228-230 (1988-09-23)
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