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Merck
CN

61990

Leu-Gly-Gly

≥99.0% (sum of enantiomers, TLC)

Synonym(s):

L-Leucyl-glycyl-glycine

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NH2)CONHCH2CONHCH2COOH
CAS Number:
Molecular Weight:
245.28
EC Number:
214-698-1
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
1728928
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InChI

1S/C10H19N3O4/c1-6(2)3-7(11)10(17)13-4-8(14)12-5-9(15)16/h6-7H,3-5,11H2,1-2H3,(H,12,14)(H,13,17)(H,15,16)/t7-/m0/s1

InChI key

VWHGTYCRDRBSFI-ZETCQYMHSA-N

SMILES string

CC(C)C[C@H](N)C(=O)NCC(=O)NCC(O)=O

assay

≥99.0% (sum of enantiomers, TLC)

optical activity

[α]20/D +59±2°, c = 2% in H2O

impurities

≤1% Leu + Gly

mp

~220 °C (dec.)

Other Notes

Substrate for the assay of aminopeptidase; and brain aminopeptidase

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N. Marks et al.
Methods in Enzymology, 19, 534-534 (1970)
E.L. Smith
Methods in Enzymology, 2, 83-83 (1955)
M Hayashi et al.
Journal of biochemistry, 87(5), 1403-1411 (1980-05-01)
Aminotripeptidase [EC 3.4.11.4] was purified from monkey brain by a five-step procedure comprising extraction from brain homogenate, ammonium sulfate fractionation, DEAE-cellulose chromatography, hydroxylapatide chromatography, and Sephadex G-200 gel filtration. A purification of 1,100-fold over the homogenate was achieved and the

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