63175
4-Maleimidobutyric acid N-hydroxysuccinimide ester
≥98.0% (HPLC)
Synonym(s):
4-Maleimidobutyric acid N-succinimidyl ester, N-(γ-Maleimidobutyryloxy)succinimide, N-Succinimidyl 4-maleimidobutyrate, GMBS
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About This Item
Empirical Formula (Hill Notation):
C12H12N2O6
CAS Number:
Molecular Weight:
280.23
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
6427689
Assay:
≥98.0% (HPLC)
Quality Segment
assay
≥98.0% (HPLC)
reaction suitability
reagent type: linker
technique(s)
targeted protein degradation: suitable
mp
123-129 °C
functional group
NHS ester
storage temp.
2-8°C
SMILES string
O=C1N(CCCC(ON2C(CCC2=O)=O)=O)C(C=C1)=O
InChI
1S/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2
InChI key
PVGATNRYUYNBHO-UHFFFAOYSA-N
Application
A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Provides a 7-atom linker.
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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