Merck
CN
All Photos(3)

Documents

65363

Supelco

(R)-(−)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride

for chiral derivatization, LiChropur, ≥99.0%

Sign Into View Organizational & Contract Pricing

Synonym(s):
(R)-(−)-MTPA-Cl, Mosher’s acid chloride
Linear Formula:
C6H5C(OCH3)(CF3)COCl
CAS Number:
Molecular Weight:
252.62
Beilstein:
3591563
MDL number:
PubChem Substance ID:

grade

for chiral derivatization

Quality Level

product line

ChiraSelect

Assay

≥99.0% (AT)
≥99.0%

optical activity

[α]20/D −137±2°, c = 6.4% in carbon tetrachloride

optical purity

enantiomeric ratio: ≥99.5:0.5 (GC)

quality

LiChropur

technique(s)

HPLC: suitable

refractive index

n20/D 1.469
n20/D 1.47 (lit.)

bp

213-214 °C (lit.)

density

1.35 g/mL at 25 °C (lit.)

shipped in

wet ice

storage temp.

−20°C

SMILES string

CO[C@](C(Cl)=O)(c1ccccc1)C(F)(F)F

InChI

1S/C10H8ClF3O2/c1-16-9(8(11)15,10(12,13)14)7-5-3-2-4-6-7/h2-6H,1H3/t9-/m0/s1

InChI key

PAORVUMOXXAMPL-VIFPVBQESA-N

Looking for similar products? Visit Product Comparison Guide

General description

(R)-(-)-a-Methoxy-a-(trifluoromethyl)phenylacetyl chloride (Mosher′s acid chloride) is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.

Application

It was used for derivatizing D-arabinitol and L-arabinitol samples for high performance thin layer chromatography (HPTLC) analysis for studying resolution of the diastereoisomer.
Ready-to-use reagent for the determination of the enantiomeric purity of alcohols and amines after derivatization; doi:10.1038/nprot.2007.354

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Please note that R(-)-MTPA-Cl is derived from S(-)-MTPA

Recommended products

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

ChiraSelect is a trademark of Sigma-Aldrich Co. LLC
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

192.2 °F - closed cup

Flash Point(C)

89 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Michael North
Principles and Applications of Stereochemistry, 112-112 (1998)
Michael North
Principles and Applications of Stereochemistry, 112-112 (1998)
S. Yamaguchi et al.
Asymmetric Synthesis, 1 (1983)
Characterization of GDP-alpha-D-arabinopyranose, the precursor of D-Arap in Leishmania major lipophosphoglycan.
Schneider, Pascal, Malcolm J. McConville, and M. A. Ferguson.
The Journal of Biological Chemistry, 269.28, 18332-18337 (1994)
J.A. Dale et al.
Journal of the American Chemical Society, 95, 512-512 (1973)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service