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Merck
CN

67805

Supelco

Idebenone

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C19H30O5
CAS Number:
58186-27-9
Molecular Weight:
338.44
MDL number:
MFCD00274552
UNSPSC Code:
41116107
PubChem Substance ID:
329760681
NACRES:
NA.24

Key Documents

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grade

analytical standard

Quality Level

100

Assay

≥97.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O

InChI

1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3

InChI key

JGPMMRGNQUBGND-UHFFFAOYSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6464
BCCK6000
BCCK5999
BCCD5091
BCCC1147

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Caterina Tonon et al.
Expert opinion on pharmacotherapy, 9(13), 2327-2337 (2008-08-20)
Friedreich's ataxia is an autosomal recessive neurodegenerative disease where impaired mitochondrial function and excessive production of free radicals play a central pathogenetic role. Idebenone, a synthetic analogue of coenzyme Q, is a powerful antioxidant that was first administrated to Friedreich's
Esfandiar J Sabet-Peyman et al.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 32(1), 54-57 (2012-01-25)
A 31-year-old woman developed subacute bilateral visual loss over a 2-week period. Two months later, the diagnosis of Leber hereditary optic neuropathy (LHON) 11778/ND4 was established and the patient was treated with 900 mg of idebenone daily. Over the ensuing
Claudia Carbone et al.
Expert opinion on drug delivery, 9(11), 1377-1392 (2012-10-23)
Idebenone (IDE) is an antioxidant compound, structurally related to coenzyme Q10. Its therapeutic potential is growing in different application areas, as demonstrated by the number of experimental works and patents produced in very recent years. Cyclodextrin inclusion complexes, liposomes, microemulsions
M Suno et al.
Archives of gerontology and geriatrics, 8(3), 299-305 (1989-05-01)
The effects of idebenone on the swelling of rat brain mitochondria were studied. When FeCl3 was added to a mitochondrial suspension, a pronounced mitochondrial swelling occurred accompanied by the production of lipid peroxide; the two phenomena were closely correlated (r
Idebenone - monograph.
Alternative medicine review : a journal of clinical therapeutic, 6(1), 83-86 (2001-02-24)
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