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Merck
CN

68253

Sodium 3-methyl-2-oxobutyrate

purum, ≥97.0% (NT)

Synonym(s):

α-Ketoisovaleric acid sodium salt, 2-Keto-3-methylbutyric acid sodium salt, 3-Methyl-2-oxobutanoic acid sodium salt, 3-Methyl-2-oxobutyric acid sodium salt, Ketovaline sodium salt

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About This Item

Linear Formula:
(CH3)2CHCOCOONa
CAS Number:
Molecular Weight:
138.10
EC Number:
223-062-2
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
4334552
MDL number:
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InChI key

WIQBZDCJCRFGKA-UHFFFAOYSA-M

InChI

1S/C5H8O3.Na/c1-3(2)4(6)5(7)8;/h3H,1-2H3,(H,7,8);/q;+1/p-1

SMILES string

[Na+].CC(C)C(=O)C([O-])=O

grade

purum

assay

≥97.0% (NT)

mp

220-230 °C (dec.) (lit.)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Benjamin F Miller et al.
The Journal of physiology, 567(Pt 3), 1021-1033 (2005-07-09)
We hypothesized that an acute bout of strenuous, non-damaging exercise would increase rates of protein synthesis of collagen in tendon and skeletal muscle but these would be less than those of muscle myofibrillar and sarcoplasmic proteins. Two groups (n =
Susanne Textor et al.
Plant physiology, 144(1), 60-71 (2007-03-21)
Chain elongated, methionine (Met)-derived glucosinolates are a major class of secondary metabolites in Arabidopsis (Arabidopsis thaliana). The key enzymatic step in determining the length of the chain is the condensation of acetyl-coenzyme A with a series of omega-methylthio-2-oxoalkanoic acids, catalyzed
Nayden Koon et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(22), 8295-8300 (2004-05-26)
The leucine biosynthetic pathway is essential for the growth of Mycobacterium tuberculosis and is a potential target for the design of new anti-tuberculosis drugs. The crystal structure of alpha-isopropylmalate synthase, which catalyzes the first committed step in this pathway, has
P H Bisschop et al.
The Journal of clinical endocrinology and metabolism, 88(8), 3801-3805 (2003-08-14)
Because insulin is an important regulator of protein metabolism, we hypothesized that physiological modulation of insulin secretion, by means of extreme variations in dietary carbohydrate content, affects postabsorptive protein metabolism. Therefore, we studied the effects of three isocaloric diets with
Frances H A Huisman et al.
Biochemistry, 51(11), 2289-2297 (2012-02-23)
α-Isopropylmalate synthase (α-IPMS) catalyzes the metal-dependent aldol reaction between α-ketoisovalerate (α-KIV) and acetyl-coenzyme A (AcCoA) to give α-isopropylmalate (α-IPM). This reaction is the first committed step in the biosynthesis of leucine in bacteria. α-IPMS is homodimeric, with monomers consisting of

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