69020
Fomepizole
purum, ≥97.0% (GC)
Synonym(s):
4-Methylpyrazole
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About This Item
Empirical Formula (Hill Notation):
C4H6N2
CAS Number:
Molecular Weight:
82.10
EC Number:
231-445-0
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
105204
MDL number:
grade
purum
assay
≥97.0% (GC)
refractive index
n20/D 1.495
bp
99-100 °C/6 mmHg (lit.)
density
0.993 g/mL at 25 °C (lit.)
SMILES string
Cc1cn[nH]c1
InChI
1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
InChI key
RIKMMFOAQPJVMX-UHFFFAOYSA-N
Gene Information
human ... ADH1A(124), ADH1B(125), ADH1C(126)
Application
Useful as an antidote in methanol and ethylene glycol poisoning.
Biochem/physiol Actions
Alcohol dehydrogenase inhibitor
Other Notes
Inhibitor of alcohol dehydrogenase
Regulatory Information
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R Blomstrand et al.
Proceedings of the National Academy of Sciences of the United States of America, 76(7), 3499-3503 (1979-07-01)
4-Methylpyrazole, in a dose producing inhibition of alcohol dehydrogenase (alcohol:NAD(+) oxidoreductase, EC 1.1.1.1), was given alone or together with ethanol (10%) as sole drinking fluid to growing rats for up to 38 weeks. Their weight curves remained normal. Electron microscopy
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