69400
6-Methyl-2-thiouracil
purum, ≥98.0% S basis (elemental analysis)
Synonym(s):
Basethyrin, Methiocil, Thiothymin, 4-Hydroxy-2-mercapto 6-methylpyrimidine, MZU
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About This Item
Empirical Formula (Hill Notation):
C5H6N2OS
CAS Number:
Molecular Weight:
142.18
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-252-3
Beilstein/REAXYS Number:
115648
MDL number:
Assay:
≥98.0% S basis (elemental analysis)
Form:
crystals
InChI key
HWGBHCRJGXAGEU-UHFFFAOYSA-N
InChI
1S/C5H6N2OS/c1-3-2-4(8)7-5(9)6-3/h2H,1H3,(H2,6,7,8,9)
SMILES string
CC1=CC(=O)NC(=S)N1
grade
purum
assay
≥98.0% S basis (elemental analysis)
form
crystals
mp
~330 °C (dec.) (lit.)
Quality Level
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General description
6-Methyl-2-thiouracil possesses antithyroid activity.
Application
6-Methyl-2-thiouracil can be used in:
- Synthesis of luminescent gold(I) thiouracilate complexes as emissive materials.
- Synthesis of uracil-containing histone deacetylase inhibitors.
- Synthesis of S-dihydro-alkylthio-benzyl-oxopyrimidines (S-DABOs) based anti-HIV agents.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors.
Mugnaini C, et al.
Bioorganic & Medicinal Chemistry Letters, 16(13), 3541-3544 (2006)
Antithyroid Drugs and their Analogues Protect Against Peroxynitrite-Mediated Protein Tyrosine Nitration-A Mechanistic Study.
Bhabak KP and Mugesh G
Chemistry?A European Journal , 16(4), 1175-1185 (2010)
Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.
Mai A, et al.
Journal of Medicinal Chemistry, 49(20), 6046-6056 (2006)
F R Lima et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(6), 2028-2038 (2001-03-14)
The postnatal development of rat microglia is marked by an important increase in the number of microglial cells and the growth of their ramified processes. We studied the role of thyroid hormone in microglial development. The distribution and morphology of
S Nishida et al.
FEBS letters, 416(1), 69-71 (1997-11-22)
Alterations in the superoxide dismutase (SOD) content of thyroid tissues occurring in association with thyroid dysfunction have been reported. In this study, the Mn-SOD content was found to increase in thyroid tissues of rats administered thyroid stimulating hormone (TSH) and
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