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Merck
CN

69412

CDP-glycerol sodium salt

≥95.0% (HPLC)

Synonym(s):

Cytidine 5′-(trihydrogen diphosphate) P′-(2,3-dihydroxypropyl) ester sodium salt, Cytidine 5′-diphosphate glycerol sodium salt, Cytidine 5′-pyrophosphate 2,3-dihydroxypropyl ester sodium salt

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About This Item

Empirical Formula (Hill Notation):
C12H21N3O13P2 · xNa+
CAS Number:
6665-99-2
Molecular Weight:
477.26 (free acid basis)
UNSPSC Code:
41116107

Key Documents

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InChI

1S/C9H15N3O9P2.C3H8O3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-23(18)21-22(16)17;4-1-3(6)2-5/h1-2,4,6-8,13-14,22-23H,3H2,(H,16,17)(H2,10,11,15);3-6H,1-2H2

InChI key

DZUKQJZKHOQCIU-UHFFFAOYSA-N

SMILES string

O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1COP(OP(O)(OCC(O)CO)=O)(O)=O

assay

≥95.0% (HPLC)

form

powder

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

CDP-glycerol is a substrate for manganese-dependent ADP-ribose/CDP-alcohol diphosphatase and is part of the purine metabolism and glycerophospholipid metabolic pathways.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Stephanie Brown et al.
Annual review of microbiology, 67, 313-336 (2013-09-13)
The peptidoglycan layers of many gram-positive bacteria are densely functionalized with anionic glycopolymers known as wall teichoic acids (WTAs). These polymers play crucial roles in cell shape determination, regulation of cell division, and other fundamental aspects of gram-positive bacterial physiology.
Volker Winstel et al.
mBio, 5(2), e00869-e00869 (2014-04-10)
ABSTRACT The major clonal lineages of the human pathogen Staphylococcus aureus produce cell wall-anchored anionic poly-ribitol-phosphate (RboP) wall teichoic acids (WTA) substituted with d-Alanine and N-acetyl-d-glucosamine. The phylogenetically isolated S. aureus ST395 lineage has recently been found to produce a unique
Stephanie Brown et al.
Chemistry & biology, 15(1), 12-21 (2008-01-25)
Resistance to every family of clinically used antibiotics has emerged, and there is a pressing need to explore unique antibacterial targets. Wall teichoic acids (WTAs) are anionic polymers that coat the cell walls of many Gram-positive bacteria. Because WTAs play
H G Rittenhouse et al.
Journal of neurochemistry, 36(3), 991-999 (1981-03-01)
Enzymatic hydrolysis of the pyrophosphate bond of CDP-diglyceride (CDP-DG), previously shown to occur in bacteria, is demonstrable in mammalian tissues. Activity was enriched in a lysosomal fraction obtained from guinea pig cerebral cortex and was purified 92-fold relative to the
Stephanie Brown et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(46), 18909-18914 (2012-10-03)
Staphylococcus aureus peptidoglycan (PG) is densely functionalized with anionic polymers called wall teichoic acids (WTAs). These polymers contain three tailoring modifications: d-alanylation, α-O-GlcNAcylation, and β-O-GlcNAcylation. Here we describe the discovery and biochemical characterization of a unique glycosyltransferase, TarS, that attaches

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