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69478

N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane

Name: N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane
Brand: SIAL

with 1% trimethylchlorosilane, for GC derivatization, LiChropur^™

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₂F₃NOSi

CAS Number:

24589-78-4

Molecular Weight:

199.25

UNSPSC Code:

23151817

PubChem Substance ID:

329761687

NACRES:

NA.22

Beilstein/REAXYS Number:

1941550

MDL number:

MFCD00000411

Assay:

≥97.0%

Form:

liquid

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Product Name

N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane, derivatization grade (GC derivatization), LiChropur^™

grade

derivatization grade (GC derivatization)

Quality Level

100

assay

≥97.0%

form

liquid

quality

LiChropur^™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.378

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

Related Categories

Analytical Reagents

Chemical Synthesis

Chromatography & Spectroscopy Reagents

Silanes

General description

Silylation can be performed by adding N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MTFA) during analysis of fluorometabolites via gas chromatography-mass spectrometry (GC-MS).

Application

Addition of Trimethylchlorosilane aids in the derivatization of amides, secondary amines and hindered hydroxy groups. Most volatile of the TMS derivatives often elutes at the solvent front of the GC.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS02,GHS07

signalword

Warning

hcodes

H226,H315,H319,H335

pcodes

P210 - P261 - P280 - P304 + P340 + P312 - P370 + P378 - P403 + P235

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

78.8 °F - closed cup

flash_point_c

26 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Filamentous fungal biofilm for production of human drug metabolites.

Amadio, Jessica, Eoin Casey, and Cormac D. Murphy.

Applied Microbiology and Biotechnology, 97 (13), 5955-5963 (2013)

Utilization of a deuterated derivatization agent to synthesize internal standards for gas chromatography-tandem mass spectrometry quantification of silylated metabolites.

Stina K Lien et al.

Journal of chromatography. A, 1247, 118-124 (2012-06-15)

GC-MS analysis of silylated metabolites is a sensitive method that covers important metabolite groups such as sugars, amino acids and non-amino organic acids, and it has become one of the most important analytical methods for exploring the metabolome. Absolute quantitative

Standardizing GC-MS metabolomics.

Harin Kanani et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 871(2), 191-201 (2008-06-10)

Metabolomics being the most recently introduced "omic" analytical platform is currently at its development phase. For the metabolomics to be broadly deployed to biological and clinical research and practice, issues regarding data validation and reproducibility need to be resolved. Gas

Simultaneous determination of benzophenone-type UV filters in water and soil by gas chromatography-mass spectrometry.

Hee-Kyung Jeon et al.

Journal of chromatography. A, 1131(1-2), 192-202 (2006-08-08)

A novel method has been developed to simultaneously determine and quantify seven organic UV filters employing liquid (solid)-liquid extraction, derivatization with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA) and gas chromatography with mass spectrometric detection in various environmental matrices. The UV filters determined were:

Enhancement of chemical derivatization of steroids by gas chromatography/mass spectrometry (GC/MS).

John A Bowden et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(27), 3237-3242 (2009-08-21)

Steroid derivatization was investigated by varying the experimental parameters (reagent, reaction time, and reaction temperature) to determine the optimal conditions for individual steroids, and for larger subsets. Three methods of derivatization enhancement were also investigated: the use of sonication, the

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Global Trade Item Number

SKU	GTIN
69478-1ML-F	04061832778914
69478-5ML-F	04061832778938
69478-10X1ML-F	04061832778907
69478-10X0.1ML-F	04061837684043

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