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Merck
CN

69577

Sigma-Aldrich

α-Methyl-DL-tyrosine

≥95% (NT)

Synonym(s):

DL-2-Methyl-3-(4-hydroxyphenyl)alanine, AMPT

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About This Item

Linear Formula:
4-(HO)C6H4CH2C(CH3)(NH2)CO2H
CAS Number:
Molecular Weight:
195.22
Beilstein:
2938704
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
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Assay

≥95% (NT)

form

powder

ign. residue

≤0.05%

mp

>300 °C (lit.)

application(s)

peptide synthesis

SMILES string

CC(N)(Cc1ccc(O)cc1)C(O)=O

InChI

1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)

InChI key

NHTGHBARYWONDQ-UHFFFAOYSA-N

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Other Notes

Inhibitor (Ki 5 uM) of tyrosine hydroxylase

Regulatory Information

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Tyrosine hydroxylase inhibitors.
K E Moore et al.
Federation proceedings, 30(3), 859-870 (1971-05-01)
Breg Braak et al.
European journal of nuclear medicine and molecular imaging, 39(4), 642-650 (2011-12-14)
Functional dyspepsia (FD) is a chronic condition characterized by upper abdominal symptoms without an identifiable cause. While the serotonergic system is thought to play a key role in the regulation of gut physiology, the role of the dopaminergic system, which
Marcelo M S Lima et al.
CNS & neurological disorders drug targets, 11(4), 359-368 (2012-04-10)
The nigrostriatal pathway is very likely involved in sleep regulation, considering the occurrence and high prevalence of sleep-related disorders in patients with Parkinson's disease. Indeed, dopaminergic neurons in the ventral tegmental area were recently shown to fire in bursts during
Simona Grob et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(8), 1945-1952 (2012-04-12)
Disturbances in reward processing have been implicated in bulimia nervosa (BN). Abnormalities in processing reward-related stimuli might be linked to dysfunctions of the catecholaminergic neurotransmitter system, but findings have been inconclusive. A powerful way to investigate the relationship between catecholaminergic
Radha Chaube et al.
Endocrine, 40(3), 394-399 (2011-10-14)
The brain is a target for organizational and activational effects of oestrogens synthesized de novo or transported from the peripheral organs. A neuroprotective role of oestrogens has been documented in a variety of vertebrates. In the present study in the

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