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Merck
CN

69577

α-Methyl-DL-tyrosine

≥95% (NT)

Synonym(s):

DL-2-Methyl-3-(4-hydroxyphenyl)alanine, AMPT

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About This Item

Linear Formula:
4-(HO)C6H4CH2C(CH3)(NH2)CO2H
CAS Number:
Molecular Weight:
195.22
EC Number:
211-523-0
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
2938704
MDL number:
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InChI key

NHTGHBARYWONDQ-UHFFFAOYSA-N

InChI

1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)

SMILES string

CC(N)(Cc1ccc(O)cc1)C(O)=O

assay

≥95% (NT)

form

powder

ign. residue

≤0.05%

mp

>300 °C (lit.)

application(s)

peptide synthesis

Other Notes

Inhibitor (Ki 5 uM) of tyrosine hydroxylase

Regulatory Information

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Tyrosine hydroxylase inhibitors.
K E Moore et al.
Federation proceedings, 30(3), 859-870 (1971-05-01)
Ewa Bromek et al.
Journal of neurochemistry, 118(5), 806-815 (2011-06-10)
The cytochrome P450-mediated synthesis of dopamine from tyramine has been shown in vitro. The aim of the present study was to demonstrate the ability of rat cytochrome P450 (CYP) 2D to synthesize dopamine from tyramine in the brain in vivo.
Kinuyo Iwata et al.
The Journal of reproduction and development, 57(3), 379-384 (2011-03-02)
Ketosis is found in various pathophysiological conditions, including diabetes and starvation, that are accompanied by suppression of gonadal activity. The aim of the present study was to determine the role of ketone body in the brain in regulating pulsatile luteinizing
Yih-Shou Hsieh et al.
Journal of psychopharmacology (Oxford, England), 25(7), 982-994 (2010-09-08)
It has been reported that neuropeptide Y (NPY) contributes to the behavioral response of amphetamine (AMPH), a psychostimulant. The present study examined whether protein kinase C (PKC)-λ signaling was involved in this action. Moreover, possible roles of glutathione peroxidase (GP)
Yu-Shang Lee et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(26), 10591-10606 (2013-06-28)
A life-threatening disability after complete spinal cord injury is urinary dysfunction, which is attributable to lack of regeneration of supraspinal pathways that control the bladder. Although numerous strategies have been proposed that can promote the regrowth of severed axons in

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