69761
(±)-Mevalonolactone
purum, ≥96.0% (T)
Synonym(s):
(±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, DL-Mevalolactone, DL-Mevalonic acid lactone
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About This Item
Empirical Formula (Hill Notation):
C6H10O3
CAS Number:
Molecular Weight:
130.14
Beilstein:
80960
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
grade
purum
Assay
≥96.0% (T)
impurities
salt, none detected
mp
24-27 °C
storage temp.
2-8°C
SMILES string
CC1(O)CCOC(=O)C1
InChI
1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3
InChI key
JYVXNLLUYHCIIH-UHFFFAOYSA-N
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Other Notes
Lactone of mevalonic acid which is a very important connecting link in the biosynthesis of isoprenoids
Disclaimer
can form fused mass at low temperatures
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
235.4 °F - closed cup
Flash Point(C)
113 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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The biosynthesis of cholesterol.
G POPJAK et al.
Advances in enzymology and related subjects of biochemistry, 22, 281-335 (1960-01-01)
R. Clayton
Quart. Rev., 19, 168-168 (1965)
J.W. Porter et al.
Biosynthesis of Isoprenoid Compounds, vol. 1 and 2 null
B. Preiss, ed.
Regulation of HMG-CoA Reductase null
Jenna Waldron et al.
Annals of clinical biochemistry, 48(Pt 3), 223-232 (2011-03-01)
Mevalonic acid (MVA) is synthesized at an early and rate-limiting step in the biosynthesis of cholesterol by the enzyme hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, and is a useful measure of statin efficacy or treatment. A liquid chromatography-tandem mass spectrometry (LC-MS/MS)
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