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Merck
CN

70015

Muscimol

Synonym(s):

3-Hydroxy-5-aminomethyl-isoxazole, 5-Aminomethyl-3-hydroxy-isoxazole, 5-Aminomethyl-3-isoxazolol, Agarine, Pantherine

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About This Item

Empirical Formula (Hill Notation):
C4H6N2O2
CAS Number:
2763-96-4
Molecular Weight:
114.10
EC Number:
220-430-4
UNSPSC Code:
12352200
PubChem Substance ID:
24886040
Beilstein/REAXYS Number:
1618960
MDL number:
MFCD00057894

Key Documents

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InChI key

ZJQHPWUVQPJPQT-UHFFFAOYSA-N

InChI

1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)

SMILES string

NCC1=CC(=O)NO1

Gene Information

rat ... Gabra2(29706)

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Biochem/physiol Actions

GABAA receptor agonist.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300,H336

Hazard Classifications

Acute Tox. 2 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Pierre Le Merre et al.
Neuron, 97(1), 83-91 (2017-12-19)
The neural circuits underlying learning and execution of goal-directed behaviors remain to be determined. Here, through electrophysiological recordings, we investigated fast sensory processing across multiple cortical areas as mice learned to lick a reward spout in response to a brief
Babak K Mansoori et al.
Experimental neurology, 254, 18-28 (2014-01-23)
A rapidly growing number of studies using inhibition of the contralesional hemisphere after stroke are reporting improvement in motor performance of the paretic hand. These studies have used different treatment onset time, duration and non-invasive methods of inhibition. Whereas these
Daniela Popa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(15), 6552-6556 (2013-04-12)
The cerebellum is an essential structure for the control of movement. It sends abundant ascending projections to the cerebral cortex via the thalamus, but its contribution to cortical activity remains largely unknown. Here we studied its influence on cortical neuronal
Thibault Cholvin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(20), 8772-8783 (2013-05-17)
Electrophysiological and neuroanatomical evidence for reciprocal connections with the medial prefrontal cortex (mPFC) and the hippocampus make the reuniens and rhomboid (ReRh) thalamic nuclei a putatively major functional link for regulations of cortico-hippocampal interactions. In a first experiment using a
Jette G Petersen et al.
Journal of medicinal chemistry, 56(3), 993-1006 (2013-01-09)
A series of bioisosteric 4-(aminomethyl)-1-hydroxypyrazole (4-AHP) analogues of muscimol, a GABA(A) receptor agonist, has been synthesized and pharmacologically characterized at native and selected recombinant GABA(A) receptors. The unsubstituted 4-AHP analogue (2a) (EC(50) 19 μM, R(max) 69%) was a moderately potent
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