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72445

Nigericin sodium salt

≥98.0% (TLC)

Synonym(s):

Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A

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About This Item

Empirical Formula (Hill Notation):
C40H67NaO11
CAS Number:
28643-80-3
Molecular Weight:
746.94
UNSPSC Code:
12352203
Beilstein/REAXYS Number:
3892398
MDL number:
MFCD00036825
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biological source

Streptomyces hygroscopicus

assay

≥98.0% (TLC)

solubility

chloroform: 10 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

[Na+].[H][C@@]1(CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@]2([H])C[C@@H](OC)[C@@H](C)[C@]3(O2)O[C@@](C)(C[C@H]3C)[C@@]4([H])CC[C@](C)(O4)[C@]5([H])O[C@]([H])(C[C@@H]5C)[C@@]6([H])O[C@@](O)(CO)[C@H](C)C[C@@H]6C

InChI

1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1

InChI key

MOYOTUKECQMGHE-PDEFJWSRSA-M

General description

Chemical structure: polyether

Biochem/physiol Actions

Polyether ionophore that disrupts membrane potential and stimulates ATPase activity in mitochondria.
Polyether ionophore that disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K+> Rb+≥ Cs+>> Na+.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

As ion-selective electrode - an efficient K+-carrier
As ion-selective electrode - an efficient K+-carrier.

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Ion-selective electrodes based on natural carboxylic polyether antibiotics.
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Analytical chemistry, 60(17), 1714-1721 (1988-09-01)
S. Cafferel-Mendez et al.
Reproduction, Nutrition, Development, 27, 921-921 (1989)
Leonid Tarassishin et al.
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