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Merck
CN

73045

Sigma-Aldrich

Methyl 4-nitrobenzenesulfonate

≥99.0% (GC)

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About This Item

Linear Formula:
O2NC6H4SO3CH3
CAS Number:
Molecular Weight:
217.20
Beilstein:
2277327
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
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Assay

≥99.0% (GC)

mp

89-92 °C (lit.)
89-92 °C

solubility

acetone: 50 mg/mL, clear, slightly yellow

SMILES string

COS(=O)(=O)c1ccc(cc1)[N+]([O-])=O

InChI

1S/C7H7NO5S/c1-13-14(11,12)7-4-2-6(3-5-7)8(9)10/h2-5H,1H3

InChI key

RMNJNEUWTBBZPT-UHFFFAOYSA-N

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Other Notes

A selective S-methylating agent for proteins and peptides; Methylation of histidine-57 in α-chymotrypsin

Regulatory Information

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Selective S-methylation of cysteine in proteins and peptides.
R L Heinrikson
Biochemical and biophysical research communications, 41(4), 967-972 (1970-11-25)
Methylation of histidine-57 in alpha-chymotrypsin by methyl p-nitrobenzenesulfonate. A new approach to enzyme modification.
Y Nakagawa et al.
Biochemistry, 9(2), 259-267 (1970-01-20)
The chemical modification of Escherichia coli ribosomes with methyl p-nitrobenzenesulfonate. Evidence for the involvement of a histidine residue in the functioning of the ribosomal peptidyl transferase.
B R Glick
Canadian journal of biochemistry, 58(12), 1345-1347 (1980-12-01)

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