73339
Guaifenesin
pharmaceutical secondary standard; traceable to USP and PhEur
Synonym(s):
Guaiacol glyceryl ether, 3-(o-Methoxyphenoxy)-1,2-propanediol, Glycerol guaiacolate, Guaifenesin
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About This Item
Empirical Formula (Hill Notation):
C10H14O4
CAS Number:
Molecular Weight:
198.22
EC Number:
202-222-5
UNSPSC Code:
41116000
MDL number:
agency
traceable to Ph. Eur. G0700000, traceable to USP 1301007
SMILES string
COc1ccccc1OCC(O)CO
InChI
1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3
InChI key
HSRJKNPTNIJEKV-UHFFFAOYSA-N
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
13 - Non Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Robert J Brosnan et al.
American journal of veterinary research, 72(12), 1569-1575 (2011-12-01)
To evaluate whether guaifenesin can prevent adverse anesthetic induction events caused by propofol and whether a guaifenesin-propofol induction combination has brief cardiovascular effects commensurate with rapid drug washout. 8 healthy adult horses. Guaifenesin was administered IV for 3 minutes followed
JeanClare Seagrave et al.
Experimental lung research, 37(10), 606-614 (2011-11-03)
Guaifenesin is widely used to alleviate symptoms of excessive mucus accumulation in the respiratory tract. However, its mechanism of action is poorly understood. The authors hypothesized that guaifenesin improves mucociliary clearance in humans by reducing mucin release, by decreasing mucus
Mehdi Hatami et al.
Biomedical chromatography : BMC, 26(7), 875-880 (2011-11-22)
A hollow fiber liquid-phase microextraction technique coupled with high-performance liquid chromatography with fluorescence detection was employed for determination and evaluation of the binding characteristics of drugs to bovine serum albumin (BSA). Enantiomers of guaifenesin (an expectorant drug) were investigated as
Helmut Albrecht et al.
Respiratory research, 13, 118-118 (2012-12-29)
Guaifenesin is a component of medicines used to improve symptoms associated with upper respiratory tract infections. Patient-reported outcome instruments are valuable for evaluating symptom improvements; however, a validated tool to assess efficacy of mucoactive drugs does not exist. We compared
Mehdi Hatami et al.
Journal of separation science, 34(21), 2933-2939 (2011-10-06)
A simple, rapid, and efficient method, dispersive liquid-liquid microextraction (DLLME) coupled with high-performance liquid chromatography-fluorescence detector, has been developed for the determination of guaifenesin (GUA) enantiomers in human urine samples after an oral dose administration of its syrup formulation. Urine
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