74650
L-Norvaline
≥99.0% (NT)
Synonym(s):
(S)-(+)-2-Aminopentanoic acid, (S)-2-Aminovaleric acid
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About This Item
Linear Formula:
CH3CH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
117.15
EC Number:
229-543-3
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
1721162
InChI
1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChI key
SNDPXSYFESPGGJ-BYPYZUCNSA-N
SMILES string
CCC[C@H](N)C(O)=O
assay
≥99.0% (NT)
optical activity
[α]20/D +25±1°, c = 10% in 20% HCl
ign. residue
≤0.05%
mp
>300 °C (lit.)
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Other Notes
Competitive inhibitor of ornithine carbamyltransferase (transcarbamylase)
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M. Nakamura et al.
Methods in Enzymology, 17A, 286-286 (1970)
Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. II. Multiple binding sites for carbamyl-P and L-norvaline, correlation with steady state kinetics.
M Marshall et al.
The Journal of biological chemistry, 247(6), 1654-1668 (1972-03-25)
Iris Thondorf et al.
Bioorganic & medicinal chemistry, 19(21), 6409-6418 (2011-10-01)
The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been performed on its natural and synthetic
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