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Merck
CN

74650

Sigma-Aldrich

L-Norvaline

≥99.0% (NT)

Synonym(s):

(S)-(+)-2-Aminopentanoic acid, (S)-2-Aminovaleric acid

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About This Item

Linear Formula:
CH3CH2CH2CH(NH2)CO2H
CAS Number:
6600-40-4
Molecular Weight:
117.15
Beilstein:
1721162
EC Number:
229-543-3
MDL number:
MFCD00064421
UNSPSC Code:
12352200

Key Documents

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Assay

≥99.0% (NT)

optical activity

[α]20/D +25±1°, c = 10% in 20% HCl

ign. residue

≤0.05%

mp

>300 °C (lit.)

SMILES string

CCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChI key

SNDPXSYFESPGGJ-BYPYZUCNSA-N

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Other Notes

Competitive inhibitor of ornithine carbamyltransferase (transcarbamylase)

Regulatory Information

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M. Nakamura et al.
Methods in Enzymology, 17A, 286-286 (1970)
Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. II. Multiple binding sites for carbamyl-P and L-norvaline, correlation with steady state kinetics.
M Marshall et al.
The Journal of biological chemistry, 247(6), 1654-1668 (1972-03-25)
Iris Thondorf et al.
Bioorganic & medicinal chemistry, 19(21), 6409-6418 (2011-10-01)
The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been performed on its natural and synthetic

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