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74777

Astragaloside IV

Name: Astragaloside IV
Brand: SIAL

>98.0%

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About This Item

Empirical Formula (Hill Notation):

C₄₁H₆₈O₁₄

CAS Number:

84687-43-4

Molecular Weight:

784.97

NACRES:

NA.85

PubChem Substance ID:

329765850

UNSPSC Code:

41106200

MDL number:

MFCD16036240

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Quality Level

100

assay

≥98.0% (TLC), >98.0%

form

powder

SMILES string

CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]2[C@@H](O)C[C@@]3(C)[C@@H]4C[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@H]6C(C)(C)[C@H](CC[C@@]67C[C@@]47CC[C@]23C)O[C@@H]8OC[C@@H](O)[C@H](O)[C@H]8O

InChI

1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1

InChI key

QMNWISYXSJWHRY-YLNUDOOFSA-N

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Biochem/physiol Actions

Anti-inflammatory.

Other Notes

Chemical constituent of Astragali radix

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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[Inhibitory effects of astragaloside IV on cytochrome P450 enzyme of rat liver microsomes].

Wenya Shan et al.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(1), 85-88 (2012-06-30)

To provide a scientific basis for the drug-combination and aim to examine whether astragaloside IV has the impact on the cytochrome P450 enzymes. Tolbutamide, chlorzoxazone, coumarin, nifedipine, and phenacetin were as probe substrates of rat CYP2C9, CYP2E1, CYP2A6, CYP3A4, and

Astragaloside IV, a novel antioxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo.

Dingkun Gui et al.

PloS one, 7(6), e39824-e39824 (2012-06-30)

Glucose-induced reactive oxygen species (ROS) production initiates podocyte apoptosis, which represents a novel early mechanism leading to diabetic nephropathy (DN). Here, we tested the hypothesis that Astragaloside IV(AS-IV) exerts antioxidant and antiapoptotic effects on podocytes under diabetic conditions. Apoptosis, albuminuria

[Protective effects of astragaloside IV on high-glucose-induced damage of retinal ganglion cells].

Ming Hao et al.

Zhonghua yi xue za zhi, 92(30), 2104-2107 (2012-11-20)

To explore the protective effects of astragaloside IV on retinal ganglion cells (RGC) incubated under high glucose. Cultured RGC-5 were divided into 3 groups: control, high glucose and high glucose+astragaloside IV. The survival rate of cell was measured by CCK-8

I. Kitagawa et al.

Chemical & Pharmaceutical Bulletin, 31, 698-698 (1983)

Topical astragaloside IV-releasing hydrogel improves healing of skin wounds in vivo.

Li-Hua Peng et al.

Biological & pharmaceutical bulletin, 35(6), 881-888 (2012-06-13)

Topical delivery of therapeutic agents at the time of injury to accelerate skin repair and prevent the formation of scars during the wound healing process has received increasing attention and represents a novel regenerative and prophylactic strategy for wound treatment.

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Global Trade Item Number

SKU	GTIN
74777-1MG	04061832891781

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