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Merck
CN

74834

Glycine

BioXtra, ≥99.0% (NT)

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:
NH2CH2COOH
CAS Number:
56-40-6
Molecular Weight:
75.07
EC Number:
200-272-2
UNSPSC Code:
12161900
MDL number:
MFCD00008131
Beilstein/REAXYS Number:
635782

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product line

BioXtra

assay

≥99.0% (NT)

impurities

≤0.3% foreign amino acids

ign. residue

≤0.1% (as SO4)

loss

≤0.05% loss on drying, 20°C (HV)

pKa (25 °C)

(1) 2.35, (2) 9.60, 2.35

mp

240 °C (dec.) (lit.), ~250 °C (dec.)

solubility

hydrochloric acid: 1 M at 20 °C, clear

anion traces

chloride (Cl-): ≤50 mg/kg, sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, NH4+: ≤200 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

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Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

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Eva S Schaffert et al.
Bioorganic & medicinal chemistry, 19(21), 6492-6504 (2011-09-24)
1,5-Disubstituted and 5-monosubstituted aminomethyltetrazole derivatives derived from glycine were synthesized employing a TMSN(3)-modified variant of the Ugi reaction as a key step. All compounds were evaluated regarding their inhibitory potency and subtype selectivity at the four murine GABA transporter subtypes
Guifeng Kang et al.
Bioorganic & medicinal chemistry letters, 20(20), 6157-6160 (2009-05-24)
Aimed at the chemotherapy of chronic pain two kinds of analgesic pharmacophores, substituted purine and Gly-AA-OBzl, were coupled via a five-step-reaction procedure and 19 novel conjugates N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycylamino acid benzylesters were provided. On mouse-tail flick model their in vivo analgesic activities
Patrick Maillard et al.
PloS one, 6(10), e26637-e26637 (2011-11-01)
A distinctive feature of HCV is that its life cycle depends on lipoprotein metabolism. Viral morphogenesis and secretion follow the very low-density lipoprotein (VLDL) biogenesis pathway and, consequently, infectious HCV in the serum is associated with triglyceride-rich lipoproteins (TRL). Lipoprotein
Maria Luisa Gelmi et al.
Journal of medicinal chemistry, 50(9), 2245-2248 (2007-04-07)
New 3-O-glycosyl-3-demethylthiocolchicines containing natural and unnatural sugar moieties were prepared and tested on gamma-aminobutyric acid (GABA) and strychnine-sensitive glycine receptors present in rat brain and spinal cord. Two different synthetic approaches were used with the readily available 3-O-demethylthiocolchicine (1b) and
Maria Luisa Gelmi et al.
Journal of medicinal chemistry, 49(18), 5571-5577 (2006-09-01)
A novel class of 3-demethoxy-3-glycosylaminothiocolchicines (7) was prepared and tested for muscle relaxant activity. The syntheses were performed starting from the new 3-amino-3-demethoxythiocolchicine (5) prepared in good yield from 3-O-demethylthiocolchicine (1c) using the Buchwald-Hartwig reaction. The condensation of 5 with
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