74835
Dimethyl suberimidate dihydrochloride
≥98.0% (AT)
Synonym(s):
DMS, Dimethyl ester octanediimidic acid dihydrochloride
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About This Item
Linear Formula:
CH3OC(=NH)CH2(CH2)4CH2C(=NH)OCH3 · 2HCl
CAS Number:
Molecular Weight:
273.20
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
252-060-4
MDL number:
InChI key
ILKCDNKCNSNFMP-UHFFFAOYSA-N
InChI
1S/C10H20N2O2.2ClH/c1-13-9(11)7-5-3-4-6-8-10(12)14-2;;/h11-12H,3-8H2,1-2H3;2*1H
SMILES string
Cl.COC(=N)CCCCCCC(=N)OC
assay
≥98.0% (AT)
mp
213-214 °C (lit.), 215-218 °C
Gene Information
rat ... Maoa(29253), Maob(25750)
Application
Reactant involved in:
- Chemical modification of tyrosinase for coupling to produce biocatalytic enzymatic flow-through detectors
- Cross-linker for synthesis of collagen-calcium phosphate composites
Other Notes
Cross-linking reagent for the modification of proteins via amidation; Lysine specific cross-linker.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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J P Charlton et al.
The Biochemical journal, 209(3), 581-586 (1983-03-01)
Previous kinetic studies have demonstrated that the activation of cyclic AMP-dependent protein kinase by cyclic AMP involves the formation of a ternary complex of cyclic AMP, the regulatory subunit (R) and the catalytic subunit (C). It is suggested that only
M.J. Hunter et al.
Methods in Enzymology, 585-585 (1970)
G E Davies et al.
Proceedings of the National Academy of Sciences of the United States of America, 66(3), 651-656 (1970-07-01)
Amidination of aldolase, glyceraldehyde-3-phosphate dehydrogenase, tryptophan synthetase B protein, L-arabinose isomerase, and the catalytic subunit of E. coli aspartate transcarbamylase with the bifunctional reagent dimethyl suberimidate produces cross-linked proteins, with reaction predominating within oligomers. Disc electrophoresis of a modified protein
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