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Merck
CN

75110

Phyllanthin

analytical standard

Synonym(s):

(2S,3S)-(+)-1,4-Dimethoxy-2,3-diveratrylbutane

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About This Item

Empirical Formula (Hill Notation):
C24H34O6
CAS Number:
10351-88-9
Molecular Weight:
418.52
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329766183
MDL number:
MFCD17166965
Beilstein/REAXYS Number:
2066503

Key Documents

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InChI key

KFLQGJQSLUYUBF-WOJBJXKFSA-N

SMILES string

COC[C@@H](Cc1ccc(OC)c(OC)c1)[C@@H](COC)Cc2ccc(OC)c(OC)c2

InChI

1S/C24H34O6/c1-25-15-19(11-17-7-9-21(27-3)23(13-17)29-5)20(16-26-2)12-18-8-10-22(28-4)24(14-18)30-6/h7-10,13-14,19-20H,11-12,15-16H2,1-6H3/t19-,20-/m1/s1

grade

analytical standard

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

Quality Level

100

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General description

Phyllanthin is found in many Phyllanthus species. It is a lignan compound which exhibits various biochemical and pharmacological properties.

Application

Phyllanthin may be used as a reference standard for the determination of the analyte in Phyllanthus species by high-performance thin layer chromatography (HPTLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC3893
BCCB1297
BCBX4704
BCBR2043V

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Quantitative determination of phyllanthin and hypophyllanthin in Phyllanthus species by high-performance thin layer chromatography.
Tripathi AK, et al.
Phytochemical Analysis, 17(6), 394- 397 (2006)
Protective activity of phyllanthin in ethanol-treated primary culture of rat hepatocytes.
Chirdchupunseree H and Pramyothin P
Journal of Ethnopharmacology, 128(1), 172- 176 (2010)
Cong Zhao et al.
Environmental toxicology (2020-08-17)
Ischemic heart disease is an imperative cause of high morbidity and mortality globally. The cardiac ischemia/reperfusion damage occur in both reperfusion and ischemia. In this exploration, we have planned to examine the cardio-protective action of phyllanthin against the myocardial ischemic-reperfusion
Phyllanthin from Phyllanthus amarus inhibits cellular and humoral immune responses in Balb/C mice.
Ilangkovan M, et al.
Phytomedicine, 23(12), 1441- 1450 (2016)
Nguyen Duc Hanh et al.
Drug development and industrial pharmacy, 40(6), 793-802 (2013-04-19)
Phyllanthin is a major bioactive lignan component of Phyllanthus amarus, with several known biological activities. This study dealt with the isolation and physicochemical characterization of phyllanthin. Phyllanthin was isolated from P. amarus leaves by column chromatography and purified by recrystallization

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