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75320

Okadaic acid

≥92% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C44H68O13
CAS Number:
78111-17-8
Molecular Weight:
805.00
UNSPSC Code:
12352202
MDL number:
MFCD00083455
Beilstein/REAXYS Number:
4640246
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assay

≥92% (HPLC)

storage temp.

2-8°C

SMILES string

[H][C@@]1(CC[C@@]2(CC[C@@]3([H])O[C@]([H])([C@@H](O)C[C@H](C)[C@@]4([H])O[C@@]5(CCCCO5)CC[C@H]4C)C(=C)[C@@H](O)[C@]3([H])O2)O1)\C=C\[C@@H](C)[C@]6([H])CC(C)=C[C@@]7(O[C@@H](CC[C@H]7O)C[C@@](C)(O)C(O)=O)O6

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General description

Marine toxin, produced by dinoflagellates, accumulates in bivalves and sponges.

Other Notes

This product has been replaced by O4511-SIGMA | Okadaic acid from Prorocentrum concavum ≥90% (HPLC), translucent film
Tumour promoter and specific inhibitor of protein phosphatases 1 and 2A, review

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Beatriz Aranda-Orgillés et al.
PloS one, 3(10), e3507-e3507 (2008-10-25)
Mutations in the MID1 protein have been found in patients with Opitz BBB/G syndrome (OS), which is characterised by multiple malformations of the ventral midline. MID1 is a microtubule-associated protein that stabilizes microtubules and, in association with the regulatory subunit
P Cohen et al.
Trends in biochemical sciences, 15(3), 98-102 (1990-03-01)
The tumour promoter okadaic acid is a potent and specific inhibitor of protein phosphatases 1 and 2A. Here we review recent studies which demonstrate that this toxin is extremely useful for identifying biological processes that are controlled through the reversible
M A Battistone et al.
Molecular human reproduction, 19(9), 570-580 (2013-05-01)
In all mammalian species studied so far, sperm capacitation correlates with an increase in protein tyrosine (Tyr) phosphorylation mediated by a bicarbonate-dependent cAMP/protein kinase A (PKA) pathway. Recent studies in mice revealed, however, that a Src family kinase (SFK)-induced inactivation
J J Fernández et al.
Current medicinal chemistry, 9(2), 229-262 (2002-02-28)
One of the most interesting groups of substances of marine origin, from structural and pharmacological points of view are polyether toxins, which generally present a great diversity in size and potent biological activities. The subject of this review is limited
Sherzad K Rashid et al.
PloS one, 9(5), e97458-e97458 (2014-05-17)
Portal hypertension characterized by generalized vasodilatation with endothelial dysfunction affecting nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) has been suggested to involve bacterial translocation and/or the angiotensin system. The possibility that ingestion of probiotics prevents endothelial dysfunction in rats following
View All Related Papers

Global Trade Item Number

SKUGTIN
345415-25G04061836684624
345415-5G04061836684631

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