75500
Orotic acid
anhydrous, ≥98.0% (T)
Synonym(s):
2,6-Dihydroxypyrimidine-4-carboxylic acid, 6-Carboxy-2,4-dihydroxypyrimidine, 6-Carboxyuracil, Uracil-6-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C5H4N2O4
CAS Number:
Molecular Weight:
156.10
EC Number:
200-619-8
UNSPSC Code:
41106305
MDL number:
Beilstein/REAXYS Number:
383901
assay
≥98.0% (T)
impurities
≤1% water
mp
≥300 °C
SMILES string
OC(=O)C1=CC(=O)NC(=O)N1
InChI
1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)
InChI key
PXQPEWDEAKTCGB-UHFFFAOYSA-N
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Costantino Salerno et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 781(1-2), 57-71 (2002-11-27)
Urinary orotic acid determination is a useful tool for screening hereditary orotic aciduria and for differentiating the hyperammonemia disorders which cannot be readily diagnosed by amino acid chromatography, thus reducing the need for enzyme determination in tissue biopsies. This review
Hirokazu Suzuki et al.
Applied and environmental microbiology, 78(20), 7376-7383 (2012-08-14)
Counterselection systems facilitate marker-free genetic modifications in microbes by enabling positive selections for both the introduction of a marker gene into the microbe and elimination of the marker from the microbe. Here we report a counterselection system for Geobacillus kaustophilus
Izumi Miyabe et al.
PLoS genetics, 7(12), e1002407-e1002407 (2011-12-07)
Coordinated replication of eukaryotic genomes is intrinsically asymmetric, with continuous leading strand synthesis preceding discontinuous lagging strand synthesis. Here we provide two types of evidence indicating that, in fission yeast, these two biosynthetic tasks are performed by two different replicases.