76850
1,2,2,6,6-Pentamethylpiperidine
purum, ≥99.0% (GC)
Synonym(s):
PMP, Pempidine
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About This Item
Empirical Formula (Hill Notation):
C10H21N
CAS Number:
Molecular Weight:
155.28
EC Number:
201-211-2
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
103806
MDL number:
InChI key
XULIXFLCVXWHRF-UHFFFAOYSA-N
InChI
1S/C10H21N/c1-9(2)7-6-8-10(3,4)11(9)5/h6-8H2,1-5H3
SMILES string
CN1C(C)(C)CCCC1(C)C
grade
purum
assay
≥99.0% (GC)
bp
187-188 °C (lit.)
density
0.858 g/mL at 25 °C (lit.)
Other Notes
One of the most strongly basic tertiary amines (sterically hindered and nonquaternizing)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
131.0 °F - closed cup
flash_point_c
55 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
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H.Z. Sommer et al.
The Journal of Organic Chemistry, 36, 824-824 (1971)
T J Martin et al.
The Journal of pharmacology and experimental therapeutics, 254(1), 45-51 (1990-07-01)
The nature of mecamylamine's and pempidine's antagonism of nicotine in the central nervous system has not been defined clearly. Although these compounds are thought to be noncompetitive antagonists in the brain due to the fact that they do not compete
Paul Touboul et al.
European heart journal, 24(16), 1481-1487 (2003-08-16)
Dronedarone, a benzofurane derivative without iodine substituents, shares the electrophysiologic properties of amiodarone. This study was designed to determine the most appropriate dose of dronedarone for prevention of atrial fibrillation (AF) after cardioversion. Patients with persistent AF were randomly allocated
V E Gmiro et al.
Eksperimental'naia i klinicheskaia farmakologiia, 63(2), 16-20 (2000-06-02)
Pyrilene acts as a central H-cholinoblocker upon intramuscular injection at a dose of 0.02-0.08 mg/kg, and as an NMDA-blocker, when the dose is increased to 0.2-0.8 mg/kg. Similarly, amantadine exhibits the properties of H-cholinoblocker and NMDA-blocker in the dose intervals
Dean A Myers et al.
Behavioural brain research, 161(1), 39-44 (2005-05-21)
Corticosterone (CORT) micropellets were stereotaxically placed bilaterally at the dorsal margin of the central nucleus of the amygdala (CeA). Both behavioral and physiological responses were recorded (plus maze and colonic discomfort) at 7 days post-implantation. Corticosterone reduced the exploration of
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