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About This Item
Empirical Formula (Hill Notation):
C17H19N3O · HCl
CAS Number:
Molecular Weight:
317.81
EC Number:
200-793-5
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
3764617
assay
≥99.0% (TLC)
solubility
methanol: 10 mg/mL, clear, colorless
SMILES string
Cl[H].Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
InChI
1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H
InChI key
TUEJFGFQYKDAPM-UHFFFAOYSA-N
Application
α-Adrenergic blocker
Biochem/physiol Actions
α-adrenoceptor antagonist; peripheral vasodilator.
Regulatory Information
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Wei Peng et al.
Journal of photochemistry and photobiology. B, Biology, 171, 75-84 (2017-05-10)
Phentolamine is one of the most representative nonselective α-adrenoreceptor blocking agents, which have been proved to be owned various pharmacological actions. Unfortunately, whether erythrocytes in the veins intervene in biological behaviors of such drug are largely obscured. With the aid
S Morishima et al.
British journal of pharmacology, 153(7), 1485-1494 (2008-01-29)
In addition to alpha1A, alpha1B and alpha1D-adrenoceptors (ARs), putative alpha1L-ARs with a low affinity for prazosin have been proposed. The purpose of the present study was to identify the alpha1A-AR and clarify its pharmacological profile using a radioligand binding assay.
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