78170
(±)-Phenylsuccinic acid
purum, ≥99.0% (T)
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About This Item
Linear Formula:
HO2CCH2CH(C6H5)CO2H
CAS Number:
Molecular Weight:
194.18
EC Number:
211-238-1
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
1875051
MDL number:
grade
purum
assay
≥99.0% (T)
ign. residue
≤0.1%
mp
166-168 °C
SMILES string
OC(=O)CC(C(O)=O)c1ccccc1
InChI
1S/C10H10O4/c11-9(12)6-8(10(13)14)7-4-2-1-3-5-7/h1-5,8H,6H2,(H,11,12)(H,13,14)
InChI key
LVFFZQQWIZURIO-UHFFFAOYSA-N
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G K Asimakis et al.
The American journal of physiology, 249(5 Pt 2), H1009-H1016 (1985-11-01)
Adenine nucleotide efflux from isolated rat heart mitochondria was studied. Inorganic phosphate induced efflux of adenine nucleotides from the mitochondria. This efflux was inhibited by carboxyatractyloside and atractyloside. The rate of efflux showed saturation kinetics with respect to extramitochondrial phosphate
T Bruhn et al.
Journal of neuroscience research, 46(2), 198-203 (1996-10-15)
Swelling-induced release of taurine was investigated in vivo in hippocampus by microdialysis or in vitro in cultured neocortical neurons or astrocytes. Swelling was induced either by increasing the extracellular K+ concentration or by exposing the cells to hyposmotic conditions. It
T Christensen et al.
Neuroscience letters, 134(1), 71-74 (1991-12-16)
The extracellular concentration of glutamate in rat hippocampus during physiological conditions, elevated extracellular K+ and global ischemia was followed by microdialysis and subsequent determination of glutamate by HPLC. The effect of phenylsuccinate, an inhibitor of the mitochondrial dicarboxylate carrier, was
R Huang et al.
Neuroscience letters, 183(1-2), 22-26 (1995-01-02)
Phenylsuccinate is an inhibitor of cytosolic glutamate formation from extracellular glutamine in cultured cerebellar granule cell neurons, a glutamatergic preparation. It prevents anoxic cell death in these cells as indicated by decreased lactate dehydrogenase (LDH) release and by the morphological
G Palaiologos et al.
Journal of neurochemistry, 51(1), 317-320 (1988-07-01)
Based on the selective inhibition of glutamate release in cerebellar granule cells in primary cultures by the aspartate aminotransferase inhibitor, aminooxyacetic acid, and by the ketodicarboxylate carrier inhibitor, phenylsuccinate, a novel model for synthesis of transmitter glutamate is suggested: Glutamate
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