78250
4-Phenylbutyric acid
purum, ≥99.0% (HPLC)
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About This Item
Linear Formula:
C6H5(CH2)3COOH
CAS Number:
Molecular Weight:
164.20
EC Number:
217-341-8
UNSPSC Code:
12352100
MDL number:
Beilstein/REAXYS Number:
638180
grade
purum
assay
≥99.0% (HPLC)
bp
165 °C/10 mmHg (lit.)
mp
49-51 °C (lit.), 49-52 °C
SMILES string
OC(=O)CCCc1ccccc1
InChI
1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12)
InChI key
OBKXEAXTFZPCHS-UHFFFAOYSA-N
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
>235.4 °F - closed cup
flash_point_c
> 113 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
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Yuyang Du et al.
Frontiers in pharmacology, 9, 180-180 (2018-05-03)
Araloside C (AsC) is a cardioprotective triterpenoid compound that is mainly isolated from Aralia elata. This study aims to determine the effects of AsC on hypoxia-reoxygenation (H/R)-induced apoptosis in H9c2 cardiomyocytes and its underlying mechanisms. Results demonstrated that pretreatment with
Jian-Qing Wang et al.
Toxicology and applied pharmacology, 266(2), 307-316 (2012-11-24)
A recent report showed that the unfolded protein response (UPR) signaling was activated in the pathogenesis of carbon tetrachloride (CCl(4))-induced hepatic fibrosis. Phenylbutyric acid (PBA) is a well-known chemical chaperone that inhibits endoplasmic reticulum (ER) stress and unfolded protein response
Jun Liu et al.
Transplantation, 94(3), 211-217 (2012-07-14)
Although endoplasmic reticulum (ER) stress has been implicated in the pathophysiology of organ ischemia-reperfusion injury (IRI), the underlying mechanisms have yet to be fully elucidated. In particular, because tissue proinflammatory immune response is the key mediator of local IRI, how
Jeng Yie Chan et al.
Diabetes, 62(5), 1557-1568 (2013-01-01)
The normal β-cell response to obesity-associated insulin resistance is hypersecretion of insulin. Type 2 diabetes develops in subjects with β-cells that are susceptible to failure. Here, we investigated the time-dependent gene expression changes in islets of diabetes-prone db/db and diabetes-resistant
Nathalie Guffon et al.
Archives of disease in childhood, 97(12), 1081-1085 (2012-09-04)
Sodium phenylbutyrate (NaPB) is used as a treatment for urea cycle disorders (UCD). However, the available, licensed granule form has an extremely bad taste, which can compromise compliance and metabolic control. A new, taste-masked, coated-granule formulation (Luc 01) under development
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