78889
Osthole
analytical standard
Synonym(s):
7-Methoxy-8-(3-methyl-2-butenyl)coumarin, 7-Methoxy-8-isopentenylcoumarin, Osthol
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About This Item
Empirical Formula (Hill Notation):
C15H16O3
CAS Number:
Molecular Weight:
244.29
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
85151701
MDL number:
grade
analytical standard
Quality Level
assay
≥98.5% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
neat
storage temp.
2-8°C
SMILES string
COc1ccc2C=CC(=O)Oc2c1C\C=C(\C)C
InChI
1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
InChI key
MBRLOUHOWLUMFF-UHFFFAOYSA-N
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Active constituent of Cnidium monnieri, a traditional Chinese medicine used for its anti-inflammatory, analgesic, and anti-lipedemic activities. Dramatically decreased lipid accumulation in a quail model. Its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of osthole as a therapeutic agent for the treatment of neurodegenerative disorders. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.
Other Notes
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ola D Alabi et al.
Life sciences, 102(2), 105-110 (2014-03-25)
Osthole, a coumarin derivative, has been used in Chinese medicine and studies have suggested a potential use in treatment of diabetes and cancers. Therefore, we investigated the effects of osthole and other coumarins on GLUT1 activity in two cell lines
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 78889-25MG | 04061832947457 |