81162
Poly(ethylene glycol)
tested according to Ph. Eur., 300
Synonym(s):
Macrogol 300, Polyoxyethylene, PEG
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About This Item
Linear Formula:
H(OCH2CH2)nOH
CAS Number:
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352104
MDL number:
InChI
1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI key
LYCAIKOWRPUZTN-UHFFFAOYSA-N
agency
tested according to Ph. Eur.
form
liquid
mol wt
Mr 285-315
pH
6-7 (23 °C, at 10 g/l)
application(s)
pharmaceutical (small molecule)
Quality Level
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General description
Poly(ethylene glycol) (PEG) is a linear polyether of ethylene glycol (ethane-1,2-diol). This non-ionic polymer is soluble in water, benzene, ethanol, acetonitrile, and dichloromethane. It is insoluble in diethyl ether and hexane. It usually exists in the monomer and aqueous phases.
Application
Poly(ethylene glycol) has been used:
- to dissolve NEO2734 (BET and CBP/EP300 inhibitor) for drug efficacy studies in vivo
- as a drug carrier for histone deacetylase (HDAC) inhibitor ACY-1215
- to study the effects of drug-induced peripheral neuropathy
Biochem/physiol Actions
Poly(ethylene glycol) (PEG) is used in various pharmaceutical applications. This polymer occurs as a preservative and is used in biomedical applications like drug delivery systems, biosensing, and tissue engineering. PEG is also used in cosmetic ointments and creams. It is used as a binding and dispersing agent in chemical and other industries.
Features and Benefits
- Environment friendly
- Biocompatible
- Unique solvent solution
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
428.0 °F - closed cup
flash_point_c
220.00 °C - closed cup
ppe
Eyeshields, Gloves
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Application of compatibilized polymer blends in biomedical fields
Zarrintaj P, et al.
Journal of Separation Science, 511-537 (2020)
Timothy A Yap et al.
Nature medicine, 29(1), 115-126 (2023-01-20)
Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy, clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS-010759, a highly potent and selective small-molecule complex I inhibitor, into two dose-escalation phase I trials in patients with
Polymers for 3D bioprinting
Beata K
Journal of Separation Science, 337-349 (2022)
Polymers and polymeric hybrids for targeted drug delivery
Islam R and Fang J
Journal of Separation Science, 303-322 (2022)
Yiming Shi et al.
Langmuir : the ACS journal of surfaces and colloids, 29(9), 3024-3033 (2013-02-26)
Through zeta potential and surface tension measurements and a series of polymerization experiments, the role of poly(ethylene glycol) (PEG) in the process of surfactant-free polymerization of styrene (St)/methyl methacrylate (MMA) has been investigated experimentally. Nanoscale and stable copolymer particles were
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