82460
6-Propyl-2-thiouracil
purum, ≥98.0% (T)
Synonym(s):
2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone, 4-Hydroxy-2-mercapto-6-propylpyrimidine
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About This Item
Empirical Formula (Hill Notation):
C7H10N2OS
CAS Number:
Molecular Weight:
170.23
EC Number:
200-103-2
UNSPSC Code:
41106305
PubChem Substance ID:
Beilstein/REAXYS Number:
130039
MDL number:
InChI key
KNAHARQHSZJURB-UHFFFAOYSA-N
InChI
1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
SMILES string
CCCC1=CC(=O)NC(=S)N1
Gene Information
human ... DIO1(1733), TPO(7173)
grade
purum
assay
≥98.0% (T)
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Kyla M Walter et al.
General and comparative endocrinology, 272, 20-32 (2018-11-19)
Thyroid hormones (THs) regulate neurodevelopment, thus TH disruption is widely posited as a mechanism of developmental neurotoxicity for diverse environmental chemicals. Zebrafish have been proposed as an alternative model for studying the role of TH in developmental neurotoxicity. To realize
Sarah V Lipchock et al.
The American journal of clinical nutrition, 98(4), 1136-1143 (2013-09-13)
Alleles of the receptor gene TAS2R38 are responsible in part for the variation in bitter taste perception of 6-n-propylthiouracil (PROP) and structurally similar compounds (eg, glucosinolates in cruciferous vegetables). At low concentrations, people with the PAV ("taster" amino acid sequence)
Juneo F Silva et al.
Reproduction, fertility, and development, 24(7), 923-931 (2012-09-01)
The objective of this study was to evaluate fetal weight, histomorphometric changes and proliferative activity, apoptosis and angiogenesis of the placenta in rats with hypothyroidism. Thirty-six adult female rats were divided into two groups with 18 animals each: control and
Michael H Powell et al.
Neurotoxicology, 33(5), 1322-1329 (2012-09-15)
Humans and wildlife are exposed to environmental pollutants that have been shown to interfere with the thyroid hormone system and thus may affect brain development. Our goal was to expose pregnant rats to propylthiouracil (PTU) to measure the effects of
Min Chen et al.
Nature reviews. Nephrology, 8(8), 476-483 (2012-06-06)
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) refers to a group of potentially life-threatening autoimmune diseases. A recent development in this field is the recognition that certain drugs can induce AAV. Among these agents, the drug most often implicated in causing
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