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Merck
CN

82460

Sigma-Aldrich

6-Propyl-2-thiouracil

purum, ≥98.0% (T)

Synonym(s):

2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone, 4-Hydroxy-2-mercapto-6-propylpyrimidine

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About This Item

Empirical Formula (Hill Notation):
C7H10N2OS
CAS Number:
51-52-5
Molecular Weight:
170.23
Beilstein:
130039
EC Number:
200-103-2
MDL number:
MFCD00006041
UNSPSC Code:
41106305
PubChem Substance ID:
329769245

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description

enzyme inhibitor

grade

purum

Assay

≥98.0% (T)

mp

218-220 °C (lit.)
218-220 °C

SMILES string

CCCC1=CC(=O)NC(=S)N1

InChI

1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)

InChI key

KNAHARQHSZJURB-UHFFFAOYSA-N

Gene Information

human ... DIO1(1733), TPO(7173)

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Kyla M Walter et al.
General and comparative endocrinology, 272, 20-32 (2018-11-19)
Thyroid hormones (THs) regulate neurodevelopment, thus TH disruption is widely posited as a mechanism of developmental neurotoxicity for diverse environmental chemicals. Zebrafish have been proposed as an alternative model for studying the role of TH in developmental neurotoxicity. To realize
Sarah V Lipchock et al.
The American journal of clinical nutrition, 98(4), 1136-1143 (2013-09-13)
Alleles of the receptor gene TAS2R38 are responsible in part for the variation in bitter taste perception of 6-n-propylthiouracil (PROP) and structurally similar compounds (eg, glucosinolates in cruciferous vegetables). At low concentrations, people with the PAV ("taster" amino acid sequence)
Michael H Powell et al.
Neurotoxicology, 33(5), 1322-1329 (2012-09-15)
Humans and wildlife are exposed to environmental pollutants that have been shown to interfere with the thyroid hormone system and thus may affect brain development. Our goal was to expose pregnant rats to propylthiouracil (PTU) to measure the effects of
Juneo F Silva et al.
Reproduction, fertility, and development, 24(7), 923-931 (2012-09-01)
The objective of this study was to evaluate fetal weight, histomorphometric changes and proliferative activity, apoptosis and angiogenesis of the placenta in rats with hypothyroidism. Thirty-six adult female rats were divided into two groups with 18 animals each: control and
S A Degrelle et al.
Placenta, 34(1), 29-34 (2012-11-24)
The placenta plays an essential role in the fetomaternal exchanges of iodine and thyroid hormones. Propylthiouracil (PTU) is presently considered to be the treatment of choice for hyperthyroidism during the first trimester of pregnancy. Little is known on the expression
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