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Merck
CN

85549

Sigma-Aldrich

Span® 85

Synonym(s):

Sorbitan trioleate, Span® 85

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About This Item

Empirical Formula (Hill Notation):
C60H108O8
CAS Number:
26266-58-0
Molecular Weight:
957.49
EC Number:
247-569-3
MDL number:
MFCD00133820
UNSPSC Code:
12161900
PubChem Substance ID:
24888385

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description

non-ionic

refractive index

n20/D 1.476 (lit.)

viscosity

200-300 mPa.s(20 °C)

HLB value

1.8±1.1

density

0.94 g/mL at 20 °C
0.956 g/mL at 25 °C (lit.)

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC

InChI

1S/C60H108O8/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-43-46-49-56(62)65-52-54(61)59-60(68-58(64)51-48-45-42-39-36-33-30-27-24-21-18-15-12-9-6-3)55(53-66-59)67-57(63)50-47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2/h25-30,54-55,59-61H,4-24,31-53H2,1-3H3/b28-25-,29-26-,30-27+/t54-,55+,59-,60-/m1/s1

InChI key

ZBNRGEMZNWHCGA-WECPCUOASA-N

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Legal Information

Span is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

437.0 °F

Flash Point(C)

225 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Gülay Büyükköroğlu et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 109, 174-183 (2016-10-30)
Cervical cancer is one of the most life threatening types of cancer among women and is generally resistant to chemotherapy. The objective of this study was to prepare a vaginal suppository containing a chemotherapeutic agent and a genetic material that
Ming-Hsi Huang et al.
PloS one, 5(8), e12279-e12279 (2010-09-03)
Antigen sparing and cross-protective immunity are regarded as crucial in pandemic influenza vaccine development. Both targets can be achieved by adjuvantation strategy to elicit a robust and broadened immune response. We assessed the immunogenicity of an inactivated H5N1 whole-virion vaccine
Chen-Yi Chiang et al.
PLoS neglected tropical diseases, 6(5), e1645-e1645 (2012-05-23)
The major weaknesses of subunit vaccines are their low immunogenicity and poor efficacy. Adjuvants can help to overcome some of these inherent defects with subunit vaccines. Here, we evaluated the efficacy of the newly developed water-in-oil-in-water multiphase emulsion system, termed
Maik J Geerken et al.
Journal of colloid and interface science, 312(2), 460-469 (2007-05-08)
The formation of emulsions with micro-engineered silicon based arrays of micro-orifices is a relatively new technique. Until now, only the preparation of oil-in-water emulsions was studied due to the hydrophilic nature of silicon. This work evaluates the emulsification of water
Hiroaki Todo et al.
International journal of pharmaceutics, 271(1-2), 41-52 (2004-05-08)
The effect of pulmonary absorption enhancers on the stability of active ingredients is an important factor for successful inhalation therapy as well as the effect on pharmacological activity and safety. We examined the effect of pulmonary absorption enhancers on the
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