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Merck
CN

85920

Strychnine

≥97.0% (TLC)

Synonym(s):

(−)-Strychnine

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About This Item

Empirical Formula (Hill Notation):
C21H22N2O2
CAS Number:
57-24-9
Molecular Weight:
334.41
EC Number:
200-319-7
UNSPSC Code:
12352200
MDL number:
MFCD00005941
Beilstein/REAXYS Number:
52979

Key Documents

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assay

≥97.0% (TLC)

mp

284-286 °C (lit.)

SMILES string

[H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]

InChI

1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1

InChI key

QMGVPVSNSZLJIA-FVWCLLPLSA-N

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Biochem/physiol Actions

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 2

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

监管及禁止进口产品

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Strychnine--a killer from the past.
Igor Makarovsky et al.
The Israel Medical Association journal : IMAJ, 10(2), 142-145 (2008-04-25)
Yan Lu et al.
The Journal of clinical investigation, 123(9), 4050-4062 (2013-08-28)
Neuropathic pain is characterized by mechanical allodynia induced by low-threshold myelinated Aβ-fiber activation. The original gate theory of pain proposes that inhibitory interneurons in the lamina II of the spinal dorsal horn (DH) act as "gate control" units for preventing
Susanne Jonsson et al.
Neuropharmacology, 82, 69-75 (2014-04-02)
The ability of drugs of abuse to increase mesolimbic levels of dopamine is a characteristic associated with their rewarding effects. Exactly how these effects are produced by different substances is not as well characterised. Our previous work in rats has
Jhansi Dyavanapalli et al.
The Journal of physiology, 592(13), 2799-2811 (2014-05-20)
Patients with obstructive sleep apnoea experience chronic intermittent hypoxia-hypercapnia (CIHH) during sleep that elicit sympathetic overactivity and diminished parasympathetic activity to the heart, leading to hypertension and depressed baroreflex sensitivity. The parasympathetic control of heart rate arises from pre-motor cardiac
Sébastien Dutertre et al.
The Journal of biological chemistry, 287(48), 40216-40223 (2012-10-06)
Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites, and chloride channel of these receptors
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