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87962

(S,S)-(+)-Tetrandrine

Name: (<I>S</I>,<I>S</I>)-(+)-Tetrandrine
Brand: SIAL

purum, ≥96.0% (CH)

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About This Item

Empirical Formula (Hill Notation):

C₃₈H₄₂N₂O₆

CAS Number:

518-34-3

Molecular Weight:

622.75

UNSPSC Code:

12352103

MDL number:

MFCD08689909

Beilstein/REAXYS Number:

877811

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Properties

grade

purum

assay

≥96.0% (CH)

optical activity

[α]20/D +283±5°, c = 1% in chloroform

mp

219-222 °C

SMILES string

COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34

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Effective treatment with a tetrandrine/chloroquine combination for chloroquine-resistant falciparum malaria in Aotus monkeys.

Zuguang Ye et al.

Malaria journal, 12, 117-117 (2013-04-04)

In vitro evidence indicates that tetrandrine (TT) can potentiate the action of chloroquine 40-fold against choloquine-resistant Plasmodium falciparum. The key question emanating from that study is "would tetrandine and chloroquine be highly effective in a live Aotus monkey model with

Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer.

Xiaolin Li et al.

International journal of nanomedicine, 7, 5183-5190 (2012-10-12)

Paclitaxel (Ptx), one of the most widely used anticancer agents, has demonstrated extraordinary activities against a variety of solid tumors. However, the therapeutic response of Ptx is often associated with severe side effects caused by its nonspecific cytotoxic effects and

Tetrandrine citrate eliminates imatinib-resistant chronic myeloid leukemia cells in vitro and in vivo by inhibiting Bcr-Abl/β-catenin axis.

Xiao-hua Xu et al.

Journal of Zhejiang University. Science. B, 13(11), 867-874 (2012-11-06)

To evaluate the effects of tetrandrine citrate, a novel tetrandrine salt with high water solubility, on the growth of imatinib (IM)-resistant chronic myeloid leukemia (CML) in vitro and in vivo, and reveal action molecular mechanisms. Cell viability in vitro was

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