89172
Bis(2,2,2-trichloroethyl) phosphorochloridate
purum, ≥98.0% (AT)
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About This Item
Linear Formula:
(Cl3CCH2O)2P(O)Cl
CAS Number:
Molecular Weight:
379.22
EC Number:
241-650-7
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
1820707
MDL number:
grade
purum
assay
≥98.0% (AT)
mp
45-47 °C (lit.)
SMILES string
ClC(Cl)(Cl)COP(Cl)(=O)OCC(Cl)(Cl)Cl
InChI
1S/C4H4Cl7O3P/c5-3(6,7)1-13-15(11,12)14-2-4(8,9)10/h1-2H2
InChI key
ZHHCWQGVXYGWCW-UHFFFAOYSA-N
Other Notes
Building block to introduce a (2,2,2-trichloro)ethyl protected phosphate in tyrosine; for protected phosphoserine
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A Paquet
International journal of peptide and protein research, 39(1), 82-86 (1992-01-01)
Boc-Ser(PO3Tc2)-OH, Z-Ser(PO3Tc2)-OH and Fmoc-Ser(PO3Tc2)-OH, derivatives useful for peptide synthesis, have been obtained in high yields by acylation of H-Ser(PO3Tc2)-OH.CF3COOH. The latter was obtained from Boc- or Z-Ser(PO3Tc2)-OBzl by simultaneous removal of the amino- and carboxy-protecting groups by Pd-catalyzed hydrogenolysis in
A Paquet et al.
The journal of peptide research : official journal of the American Peptide Society, 50(4), 262-268 (1997-11-14)
Suitability of bis-(2,2,2-trichloro)ethyl (Tc) groups for protection of phosphate moiety in Boc-mode synthesis of phosphotyrosine peptides is demonstrated Boc-Tyr(PO3Tc2)-OH and Fmoc-Tyr(PO3Tc2)-OH were prepared by acylating H-Tyr(PO3Tc2)-OH with (Boc)2O and Fmoc-ONSu, respectively. Phosphorus introduction was achieved by phosphorylating Boc-Tyr-OBzl with Tc
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