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Merck
CN

90170

Nα-p-Tosyl-L-arginine methyl ester hydrochloride

for the determination of trypsin, ≥99.0% (AT)

Synonym(s):

TAME hydrochloride

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About This Item

Linear Formula:
H2NC(=NH)NH(CH2)3CH(NHSO2C6H4CH3)CO2CH3 · HCl
CAS Number:
1784-03-8
Molecular Weight:
378.87
EC Number:
217-235-1
UNSPSC Code:
12352200
MDL number:
MFCD00012578
Beilstein/REAXYS Number:
3922357

Key Documents

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assay

≥99.0% (AT)

optical activity

[α]20/D +9.0±1.5°, c = 1% in ethanol

quality

for the determination of trypsin

ign. residue

≤0.1%

mp

145-147 (lit.), 146-150 °C

solubility

methanol: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1

InChI

1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1

InChI key

JIQFFACVQXXHMY-YDALLXLXSA-N

Other Notes

Substrate for the assay of trypsin and thrombin ; subtilisin; plasmin; kallikrein; TAME is not attacked by chymotrypsin.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Investigation of serum trypsin and related substances. I. The quantitative demonstration of trypsinlike activity in human blood serum by a micromethod.
A M SIEGELMAN et al.
Archives of biochemistry and biophysics, 97, 159-163 (1962-04-01)
Purification and characterization of dog urinary kallikrein.
Y Matsuda et al.
Chemical & pharmaceutical bulletin, 30(7), 2512-2520 (1982-07-01)
M. Ottesen and I. Svensen et al.
Methods of Enzymatic Analysis, 5, 159-159 (1984)
G S Bedi et al.
Preparative biochemistry, 14(3), 257-279 (1984-08-01)
Kallikrein enzyme initially was isolated from rat plasma by passage of citrated plasma through a DEAE-Sephadex column at pH 7.2. The active fraction was purified to electrophoretic apparent homogeneity by precipitation to 60% ammonium sulfate saturation, sequential passage through DE-52
Rabbit plasminogen and plasmin isozymes.
F J Castellino et al.
Methods in enzymology, 45, 273-286 (1976-01-01)

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