903817
cis-3,5-Difluoropiperidine
trifluoroacetate protected, ≥95%
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About This Item
Empirical Formula (Hill Notation):
C7H8F5NO
Molecular Weight:
217.14
UNSPSC Code:
12352101
Product Name
cis-3,5-Difluoropiperidine, trifluoroacetate protected, ≥95%
assay
≥95%
form
powder
storage temp.
2-8°C
Application
Fluorinated piperidines are of interest in drugs, agrochemicals and materials science. A straightforward process developed by Glorius and coworkers allows the preparation of these motifs in a highly diastereoselective manner. The all-cis-3,5-difluoropiperidine can be directly employed in synthetic applications after TFA-deprotection.
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
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Zackaria Nairoukh et al.
Nature chemistry, 11(3), 264-270 (2019-01-22)
Piperidines and fluorine substituents are both independently indispensable components in pharmaceuticals, agrochemicals and materials. Logically, the incorporation of fluorine atoms into piperidine scaffolds is therefore an area of tremendous potential. However, synthetic approaches towards the formation of these architectures are
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