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Merck
CN

90532

N-Desisopropylpropranolol

analytical standard

Synonym(s):

(±)-1-Amino-3-(1-naphthyloxy)-2-propanol, (±)-Norpropranolol, N-Deisopropylpropranolol

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About This Item

Empirical Formula (Hill Notation):
C13H15NO2
CAS Number:
20862-11-7
Molecular Weight:
217.26
NACRES:
NA.24
PubChem Substance ID:
329769920
UNSPSC Code:
41116107
MDL number:
MFCD00526461

Key Documents

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InChI

1S/C13H15NO2/c14-8-11(15)9-16-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,15H,8-9,14H2

SMILES string

NCC(O)COC1=CC=CC2=CC=CC=C21

InChI key

ZFMCITCRZXLMDJ-UHFFFAOYSA-N

grade

analytical standard

assay

≥97.5% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤1.0% water (calc. from elemental analysis)

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

Quality Level

100

General description

N-Desisopropylpropranolol is one of the active metabolites of propranolol, a widely prescribed β-adrenergic blocking drug for treating arrhythmias, thyrotoxicosis, angina pectoris, and hypertension.

Application

N-Desisopropylpropranolol may be used as an analytical reference standard for the determination of the analyte in various biological samples by chromatography techniques.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC3402
BCBV8575

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Development and validation of a capillary zone electrophoresis method for the determination of propranolol and N-desisopropylpropranolol in human urine
Nevado JJB, et al.
Analytica Chimica Acta, 559(1), 9-14 (2006)
Versatile isocratic high-performance liquid chromatographic assay for propranolol and its basic, neutral and acidic metabolites in biological fluids
Kwong EC and Shen DD
Journal of Chromatography. B, Biomedical Sciences and Applications, 414(65), 365-379 (1987)
Rapid and simultaneous extraction of propranolol, its neutral and basic metabolites from plasma and assay by high-performance liquid chromatography
Harrison PM, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 343(1), 349-358 (1985)
An improved HPLC-MS/MS method for simultaneous quantification of propranolol and its two phase I metabolites in plasma of infants with hemangioma and its application to a comparative study of plasma concentrations
He H, et al.
Royal Society of Chemistry Advances, 8(65), 37286-37294 (2018)

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