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Merck
CN

90567

Antipyrine

reference material

Synonym(s):

2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one, Phenazone

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About This Item

Empirical Formula (Hill Notation):
C11H12N2O
CAS Number:
Molecular Weight:
188.23
EC Number:
200-486-6
UNSPSC Code:
77101502
PubChem Substance ID:
Beilstein/REAXYS Number:
157775
MDL number:
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InChI

1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3

InChI key

VEQOALNAAJBPNY-UHFFFAOYSA-N

SMILES string

CN1N(C(=O)C=C1C)c2ccccc2

grade

reference material

assay

≥98.5% (qNMR), ≥99.0% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤0.5% water

mp

109-111 °C (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Gene Information

human ... PTGS1(5742)

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Application

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Factors influencing antipyrine elimination.
I H Stevenson
British journal of clinical pharmacology, 4(3), 261-265 (1977-06-01)
L B Zavodnik et al.
Farmakologiia i toksikologiia, 52(3), 95-101 (1989-05-01)
The presented findings indicate that the determination in the blood or saliva of antipyrine concentration kinetics as well as the profile and the ratio of the products of its hydroxylation in the urine makes it possible to evaluate under clinical
Antipyrine as a model drug to study hepatic drug-metabolizing capacity.
H E Poulsen et al.
Journal of hepatology, 6(3), 374-382 (1988-06-01)
A P Viktorov et al.
Farmakologiia i toksikologiia, 53(1), 74-77 (1990-01-01)
The data about the use of "antipyrine test" in clinical practice for studying the drug oxidation peculiarities are presented. The data characterize the main pharmacokinetic properties of antipyrine as a "metabolic marker" for quantitative estimation of the effects of inductors
F Pautet et al.
Pathologie-biologie, 33(7), 777-780 (1985-09-01)
Antipyrine is widely used as a model compound to assess the hepatic metabolism in man. This drug is extensively metabolized by the hepatic microsomal drug-oxidizing system, into three main metabolites and six minor compounds of the phase I. The metabolite

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