90779
Poly(maleic anhydride-alt-1-octene), 3-(dimethylamino)-1-propylamine derivative
Synonym(s):
PMAL TM-C6
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About This Item
CAS Number:
UNSPSC Code:
12352200
description
zwitterionic
λ
0.1 % in H2O
UV absorption
λ: 260 nm Amax: ≤0.400, λ: 280 nm Amax: ≤0.150
Application
Use of "Amphipols" for delivering of membrane proteins to lipid bilayers, as activity support of membrane enzymes.
Analysis Note
enzyme traces DNases, RNases, proteases and phosphatases not detectable
Regulatory Information
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Bonnie M Gorzelle et al.
Journal of the American Chemical Society, 124(39), 11594-11595 (2002-09-26)
Amphipathic polymers ("amphipols") were introduced several years ago (Tribet, C.; Audebert, R.; Popot, J.-L. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 15047-15050) as an alternative method for solubilizing integral membrane proteins in stable, nativelike conformations. However, direct maintenance of full
J K Nagy et al.
FEBS letters, 501(2-3), 115-120 (2001-07-27)
Data are presented which suggest that a class of amphiphilic polymers known as 'amphipols' may serve as a vehicle for delivering complex integral membrane proteins into membranes. The integral membrane protein diacylglycerol kinase (DAGK) was maintained in soluble form by
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