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Merck
CN

91214

Isofraxidin

analytical standard

Synonym(s):

6,8-Dimethoxyumbelliferone, 7-Hydroxy-6,8-dimethoxychromen-2-one, 7-Hydroxy-6,8-dimethoxycoumarin

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About This Item

Empirical Formula (Hill Notation):
C11H10O5
CAS Number:
486-21-5
Molecular Weight:
222.19
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329770006
MDL number:
MFCD00221757
Beilstein/REAXYS Number:
202652

Key Documents

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InChI

1S/C11H10O5/c1-14-7-5-6-3-4-8(12)16-10(6)11(15-2)9(7)13/h3-5,13H,1-2H3

SMILES string

COc1cc2C=CC(=O)Oc2c(OC)c1O

InChI key

HOEVRHHMDJKUMZ-UHFFFAOYSA-N

grade

analytical standard

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤5.0% water

application(s)

food and beverages

format

neat

storage temp.

2-8°C

Quality Level

100

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General description

Isofraxidin is a major active constituent, isolated from Sarcandra glabra plant with a variety of biological properties such as antifatigue, antistress, anticancer, immunoaccomondating and cholagogic effects.

Application

Isofraxidin may be used as an analytical reference standard for the separartion and quantification of the analyte in Sarcandra glabra plant and Acanthopanax senticosus Harms using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH4736
BCCF6368
BCCD2763
BCCB6662
BCCB8654

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Jiaqin Liu et al.
Biopolymers, 73(4), 443-450 (2004-03-03)
The binding of isofraxidin to bovine serum albumin (BSA) was studied under physiological conditions with BSA concentration of 1.5 x 10(-6) mol x L(-1) and drug concentration in the range of 1.67 x 10(-6) mol x L(-1) to 2.0 x
Xiaofeng Niu et al.
International immunopharmacology, 14(2), 164-171 (2012-07-18)
Isofraxidin (IF) is a Coumarin compound that can be isolated from medicinal plants, such as Sarcandra glabra (Thunb.). Nakai is widely used in Asian countries for the treatment of anti-bacterial, anti-inflammatory and anti-tumour action. The present investigation was designed to
J H Kwak et al.
Journal of natural products, 64(8), 1081-1083 (2001-08-25)
Four new coumarin monoterpene ethers, artekeiskeanols A-D (1-4), and three known coumarins, isofraxidin, fraxidin, and daphnoretin, were isolated from the whole plants of Artemisia keiskeana. All structures were determined from spectral data, and that of artekeiskeanol A (1) was confirmed
Jiaqin Liu et al.
Bioorganic & medicinal chemistry, 12(2), 469-474 (2004-01-16)
This study was designed to examine the interaction of isofraxidin with human serum albumin (HSA) under physiological conditions with drug concentrations in the range of 3.3 x 10(-6) mol L(-1)-3.0x10(-5) mol L(-1) and HSA concentration at 1.5 x 10(-6) mol
Hui Sun et al.
Journal of separation science, 30(18), 3120-3126 (2007-11-17)
An HPLC with SPE method has been developed for analysis of constituents in rat blood after oral administration of the extract of Acanthopanax senticosus (ASE). The plasma sample was prepared by SPE method equipped with Oasis HLB cartridge (3cc, 60
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