916587
3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid
≥95%
Synonym(s):
Semi-flexible linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C17H23NO4
CAS Number:
Molecular Weight:
305.37
MDL number:
UNSPSC Code:
12352106
Quality Level
Assay
≥95%
form
powder
reaction suitability
reagent type: linker
functional group
Boc
carboxylic acid
storage temp.
2-8°C
SMILES string
O=C(OC(C)(C)C)N1CCC(C2=CC(C(O)=O)=CC=C2)CC1
InChI
1S/C17H23NO4/c1-17(2,3)22-16(21)18-9-7-12(8-10-18)13-5-4-6-14(11-13)15(19)20/h4-6,11-12H,7-10H2,1-3H3,(H,19,20)
InChI key
PDPYHAXCPUSEMT-UHFFFAOYSA-N
Application
3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Haifeng Tang et al.
Bioorganic & medicinal chemistry letters, 20(20), 6088-6092 (2010-09-14)
A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in
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