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Merck
CN

91703

Trifluoroacetic acid

suitable for UV/Vis spectroscopy, ≥99.0% (GC)

Synonym(s):

TFA

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About This Item

Linear Formula:
CF3COOH
CAS Number:
Molecular Weight:
114.02
EC Number:
200-929-3
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
742035
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vapor density

3.9 (vs air)

vapor pressure

97.5 mmHg ( 20 °C)

assay

≥99.0% (GC)

technique(s)

UV/Vis spectroscopy: suitable

impurities

≤0.05% water

refractive index

n20/D 1.3 (lit.)

bp

72.4 °C (lit.)

mp

−15.4 °C (lit.)

solubility

water: soluble

density

1.489 g/mL at 20 °C (lit.)

λ

1 cm path, H2O reference

UV absorption

λ: 260 nm Amax: 0.9, λ: 270 nm Amax: 0.1, λ: 280 nm Amax: 0.05, λ: 290 nm Amax: 0.04, λ: 300 nm Amax: 0.03, λ: 320 nm Amax: 0.025

SMILES string

OC(C(F)(F)F)=O

InChI

1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

DTQVDTLACAAQTR-UHFFFAOYSA-N



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pictograms

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Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 2

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

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Continuous-flow synthesis of the anti-malaria drug artemisinin.
François Lévesque et al.
Angewandte Chemie (International ed. in English), 51(7), 1706-1709 (2012-01-18)
Macro- and micromethods for the determination of serum vitamin A using trifluoroacetic acid.
J B Neeld et al.
The Journal of nutrition, 79, 454-462 (1963-04-01)
Guangfa Shi et al.
Organic letters, 17(1), 38-41 (2014-12-18)
Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in